Save up -80% on Glimepiride
Note: this is a drug discount program, not an insurance plan.
Price of Glimepiride
Amaryl 2 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Glimepiride volume of distribution
* 21.8 13.9 L (Volunteers)
* 19.8 12.7 L (Patients with Type 2 diabetes, Single Dose)
* 37.1 18.2 L (Patients with Type 2 diabetes, Multiple Dose)
What is Glimepiride
Glimepiride is the first III generation sulphonyl urea it is a very potent sulphonyl urea with long duration of action.
Glimepiride mechanism of action
The mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glimepiride likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin.
Dosage forms of Glimepiride
Sanofi Aventis Canada Inc
Humans and other mammals
Indication of Glimepiride
For concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.
Toxicity of Glimepiride
Severe hypoglycemic reactions with coma, seizure, or other neurological impairment.
Disclaimer: before buying a Glimepiride on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.