Save up -80% on Glucagon recombinant

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Glucagen

$287.631 kit (hypokit) 1mg
price without discount in nearest pharmacy. Price may vary.

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Glucagon recombinant volume of distribution

Administration of the intravenous glucagon showed dose proportionality of the pharmacokinetics between 0.25 and 2.0 mg. Calculations from a 1 mg dose showed a small volume of distribution (mean, 0.25 L/kg) and a moderate clearance (mean, 13.5 mL/min/kg). The half-life was short, ranging from 8 to 18 minutes.

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What is Glucagon recombinant

29 residue peptide hormone. Glucagon is synthesized in a special non- pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for glucagons

Glucagon recombinant mechanism of action

Glucagon binds the glucagon receptor, a G protein-coupled receptor located in the plasma membrane, which then initiates a dual signaling pathway using both adenylate cyclase activation and increased intracellular calcium. Adenylate cyclase manufactures cAMP (cyclic AMP), which activates protein kinase A (cAMP-dependent protein kinase). This enzyme, in turn, activates phosphorylase kinase, which, in turn, phosphorylates glycogen phosphorylase, converting into the active form called phosphorylase A. Phosphorylase A is the enzyme responsible for the release of glucose-1-phosphate from glycogen polymers. This yields glucose molecules to be released into the blood. Glucagon receptors are found in the liver, kidney, brain and pancreatic islet cells. The glucagon mediated signals lead to an increase in insulin excretion

Dosage forms of Glucagon recombinant

FormRouteStrength
Injection, powder, for solutionintramuscular; intravenous; subcutaneous1 mg/mL
Kit; powder for solutionintramuscular1 mg
Kit

Prescription Generics

false

International Brands

Glucagen

Synonyms

Glucagon Glucagon (recombinant dna origin)

Manufacturers

Boehringer Ingelheim Pharmaceuticals, Inc.

CAS number

16941-32-5

UNII

76LA80IG2G

State

liquid

Affected organisms

Humans and other mammals

Indication of Glucagon recombinant

For treatment of severe hypoglycemia, also used in gastrointestinal imaging

Toxicity of Glucagon recombinant

The toxic effects associated with rapid lipid mobilization and a high plasma free fatty acid (FFA) concentration produced by glucagon were evaluated. Glucagon (0.5 mg/kg of body wt) was injected intravenously into nonfasting geese. The geese developed rapid respirations and high plasma FFA levels within 15 min after the glucagon injection; three of eleven died. Control geese, injected with saline, did not exhibit toxic signs.

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