Save up -80% on Glucagon recombinant
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Glucagen
|$287.63||1 kit (hypokit) 1mg|
|price without discount in nearest pharmacy. Price may vary.|
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Glucagon recombinant volume of distribution
Administration of the intravenous glucagon showed dose proportionality of the pharmacokinetics between 0.25 and 2.0 mg. Calculations from a 1 mg dose showed a small volume of distribution (mean, 0.25 L/kg) and a moderate clearance (mean, 13.5 mL/min/kg). The half-life was short, ranging from 8 to 18 minutes.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Glucagon recombinant
29 residue peptide hormone. Glucagon is synthesized in a special non- pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for glucagons
Glucagon recombinant mechanism of action
Glucagon binds the glucagon receptor, a G protein-coupled receptor located in the plasma membrane, which then initiates a dual signaling pathway using both adenylate cyclase activation and increased intracellular calcium. Adenylate cyclase manufactures cAMP (cyclic AMP), which activates protein kinase A (cAMP-dependent protein kinase). This enzyme, in turn, activates phosphorylase kinase, which, in turn, phosphorylates glycogen phosphorylase, converting into the active form called phosphorylase A. Phosphorylase A is the enzyme responsible for the release of glucose-1-phosphate from glycogen polymers. This yields glucose molecules to be released into the blood. Glucagon receptors are found in the liver, kidney, brain and pancreatic islet cells. The glucagon mediated signals lead to an increase in insulin excretion
Dosage forms of Glucagon recombinant
|Injection, powder, for solution||intramuscular; intravenous; subcutaneous||1 mg/mL|
|Kit; powder for solution||intramuscular||1 mg|
Glucagon Glucagon (recombinant dna origin)
Boehringer Ingelheim Pharmaceuticals, Inc.
Humans and other mammals
Indication of Glucagon recombinant
For treatment of severe hypoglycemia, also used in gastrointestinal imaging
Toxicity of Glucagon recombinant
The toxic effects associated with rapid lipid mobilization and a high plasma free fatty acid (FFA) concentration produced by glucagon were evaluated. Glucagon (0.5 mg/kg of body wt) was injected intravenously into nonfasting geese. The geese developed rapid respirations and high plasma FFA levels within 15 min after the glucagon injection; three of eleven died. Control geese, injected with saline, did not exhibit toxic signs.
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