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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Glutathione

L-glutathione powder

$3.0

g

* price without discount in nearest pharmacy. Price may vary.

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Glutathione volume of distribution

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What is Glutathione

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

Glutathione mechanism of action

Glutathione (GSH) participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase. It is also important as a hydrophilic molecule that is added to lipophilic toxins and waste in the liver during biotransformation before they can become part of the bile. Glutathione is also needed for the detoxification of methylglyoxal, a toxin produced as a by-product of metabolism. This detoxification reaction is carried out by the glyoxalase system. Glyoxalase I catalyzes the conversion of methylglyoxal and reduced glutathione to S-D-Lactoyl-glutathione. Glyoxalase II catalyzes the conversion of S-D-Lactoyl Glutathione to Reduced Glutathione and D-lactate. GSH is known as a cofactor in both conjugation reactions and reduction reactions, catalyzed by glutathione S-transferase enzymes in cytosol, microsomes, and mitochondria. However, it is capable of participating in non-enzymatic conjugation with some chemicals, as it is hypothesized to do to a significant extent with n-acetyl-p-benzoquinone imine (NAPQI), the reactive cytochrome P450 reactive metabolite formed by toxic overdose of acetaminophen. Glutathione in this capacity binds to NAPQI as a suicide substrate and in the process detoxifies it, taking the place of cellular protein sulfhydryl groups which would otherwise be toxically adducted. The preferred medical treatment to an overdose of this nature, whose efficacy has been consistently supported in literature, is the administration (usually in atomized form) of N-acetylcysteine, which is used by cells to replace spent GSSG and allow a usable GSH pool.

Dosage forms of Glutathione

FormRouteStrength
Powder for solutionintraocular
Kit
Solution; kitintraocular
Prescription Generics

false

International Brands

Amo Endosol Extra

Synonyms

5-L-Glutamyl-L-cysteinylglycine gamma-L-Glutamyl-L-cysteinyl-glycine

Manufacturers

Amo Canada Company

CAS number

70-18-8

UNII

GAN16C9B8O

State

solid

Affected organisms

Humans and other mammals

Indication of Glutathione

For nutritional supplementation, also for treating dietary shortage or imbalance

Toxicity of Glutathione

ORL-MUS LD sub 50 /sub 5000 mg/kg, IPR-MUS LD sub 50 /sub 4020 mg/kg, SCU-MUS LD sub 50 /sub 5000 mg/kg, IVN-RBT LD sub 50 /sub 2000 mg/kg, IMS-MUS LD sub 50 /sub 4000 mg/kg

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