Save up -80% on Glutathione
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Glutathione
|$25.0||500 mg/200 Capsules|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Glutathione coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Glutathione every time. What are you waiting for? Claim your prescription drug card now!
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Glutathione volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Glutathione
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Glutathione mechanism of action
Glutathione (GSH) participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase. It is also important as a hydrophilic molecule that is added to lipophilic toxins and waste in the liver during biotransformation before they can become part of the bile. Glutathione is also needed for the detoxification of methylglyoxal, a toxin produced as a by-product of metabolism. This detoxification reaction is carried out by the glyoxalase system. Glyoxalase I catalyzes the conversion of methylglyoxal and reduced glutathione to S-D-Lactoyl-glutathione. Glyoxalase II catalyzes the conversion of S-D-Lactoyl Glutathione to Reduced Glutathione and D-lactate. GSH is known as a cofactor in both conjugation reactions and reduction reactions, catalyzed by glutathione S-transferase enzymes in cytosol, microsomes, and mitochondria. However, it is capable of participating in non-enzymatic conjugation with some chemicals, as it is hypothesized to do to a significant extent with n-acetyl-p-benzoquinone imine (NAPQI), the reactive cytochrome P450 reactive metabolite formed by toxic overdose of acetaminophen. Glutathione in this capacity binds to NAPQI as a suicide substrate and in the process detoxifies it, taking the place of cellular protein sulfhydryl groups which would otherwise be toxically adducted. The preferred medical treatment to an overdose of this nature, whose efficacy has been consistently supported in literature, is the administration (usually in atomized form) of N-acetylcysteine, which is used by cells to replace spent GSSG and allow a usable GSH pool.
Dosage forms of Glutathione
|Powder for solution||intraocular|
Amo Endosol Extra
Amo Canada Company
Humans and other mammals
Indication of Glutathione
For nutritional supplementation, also for treating dietary shortage or imbalance
Toxicity of Glutathione
ORL-MUS LD sub 50 /sub 5000 mg/kg, IPR-MUS LD sub 50 /sub 4020 mg/kg, SCU-MUS LD sub 50 /sub 5000 mg/kg, IVN-RBT LD sub 50 /sub 2000 mg/kg, IMS-MUS LD sub 50 /sub 4000 mg/kg
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