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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Glyburide

Diabeta 5 mg tablet

$1.36

tablet

* price without discount in nearest pharmacy. Price may vary.

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Glyburide volume of distribution

Steady state V sub d /sub =0.125 L/kg; V sub d /sub during elimination phase=0.155 L/kg.

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What is Glyburide

Glyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta; cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic beta; cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Glyburide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Glyburide appears to be completely metabolized, likely in the liver. Although its metabolites exert a small hypoglycemic effect, their contribution to glyburide’s hypoglycemic effect is thought to be clinically unimportant. Glyburide metabolites are excreted in urine and feces in approximately equal proportions. The half-life of glyburide appears to be unaffected in those with a creatinine clearance of greater than 29 ml/min/1.73m sup 2 /sup .

Glyburide mechanism of action

Sulfonylureas such as glyburide bind to ATP-sensitive potassium channels on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

Dosage forms of Glyburide

DrugDosageQuantityPrice
Glyburide2.5mg100$25.00
Glyburide5mg100 Tablet$26.90
Diabeta2.5mg30 Tablet$34.00
Diabeta5mg30 Tablet$37.00
Glyburide/Metformin2.5/500mg90 Tablet$51.00
Prescription Generics

true

International Brands

Apo Glyburide Tab 2.5mg

Synonyms

1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea 1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea

Manufacturers

Apotex Inc

CAS number

10238-21-8

UNII

SX6K58TVWC

State

solid

Affected organisms

Humans and other mammals

Indication of Glyburide

Indicated as an adjunct to diet to lower the blood glucose in patients with NIDDM whose hyperglycemia cannot be satisfactorily controlled by diet alone.

Toxicity of Glyburide

Oral rat LD sub 50 /sub : 20,000 mg/kg. Oral mouse LD sub 50 /sub : 3250 mg/kg.

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