Save up -80% on Glycerol Phenylbutyrate

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Ravicti

$4,748.691 bottle (25ml) 1.1g oral solution
price without discount in nearest pharmacy. Price may vary.

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Glycerol Phenylbutyrate volume of distribution

In healthy fasting adults who received a single oral dose of glycerol phenylbutyrate 2.9 mL/m2, peak PBA, PAA, and PAGN plasma concentrations occurred at 2 hours, 4 hours, and 4 hours, respectively.

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2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Glycerol Phenylbutyrate

Glycerol phenylbutyrate is a nitrogen-binding agent. Chemically, it is a triglyceride in which three molecules of phenylbutyrate are linked to a glycerol backbone. FDA approved on February 1, 2013.

Glycerol Phenylbutyrate mechanism of action

The toxic accumulation of ammonia in the blood and brain arise from urea cycle disorders in which patients are deficient in critical enzymes or transporters that are involved in the synthesis of urea from ammonia. Glycerol phenylbutyrate is a prodrug – the major metabolite, phenylacetate (PAA) is the molecule that binds to nitrogen. PAA conjugates with glutamine (which contains 2 molecules of nitrogen) via acetylation in the liver and kidneys to form phenylacetylglutamine (PAGN), which is excreted by the kidneys. PAGN, like urea, contains 2 moles of nitrogen and provides an alternate vehicle for waste nitrogen excretion.

Dosage forms of Glycerol Phenylbutyrate

Ravicti25ml1 bottle$4,627
Ravicti25ml20 bottles$93,268

Prescription Generics


International Brands



Glyceryl Tri-4-Phenylbutyrate GPB


Horizon Therapeutics, Llc.

CAS number






Affected organisms

Humans and other mammals

Indication of Glycerol Phenylbutyrate

Glycerol phenylbutyrate is a nitrogen-binding agent for the chronic management of adult and pediatric patients 2 years of age with urea cycle disorders (UCDs) who cannot be managed by dietary protein restriction and/or amino acid supplementation alone.

Toxicity of Glycerol Phenylbutyrate

Most common adverse reactions in 10% of patients are diarrhea, flatulence, and headache.

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