Save up -80% on Glycerol Phenylbutyrate
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Ravicti
|$4,748.69||1 bottle (25ml) 1.1g oral solution|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Ravicti coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Glycerol Phenylbutyrate every time. What are you waiting for? Claim your prescription drug card now!
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Glycerol Phenylbutyrate volume of distribution
In healthy fasting adults who received a single oral dose of glycerol phenylbutyrate 2.9 mL/m2, peak PBA, PAA, and PAGN plasma concentrations occurred at 2 hours, 4 hours, and 4 hours, respectively.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Glycerol Phenylbutyrate
Glycerol phenylbutyrate is a nitrogen-binding agent. Chemically, it is a triglyceride in which three molecules of phenylbutyrate are linked to a glycerol backbone. FDA approved on February 1, 2013.
Glycerol Phenylbutyrate mechanism of action
The toxic accumulation of ammonia in the blood and brain arise from urea cycle disorders in which patients are deficient in critical enzymes or transporters that are involved in the synthesis of urea from ammonia. Glycerol phenylbutyrate is a prodrug – the major metabolite, phenylacetate (PAA) is the molecule that binds to nitrogen. PAA conjugates with glutamine (which contains 2 molecules of nitrogen) via acetylation in the liver and kidneys to form phenylacetylglutamine (PAGN), which is excreted by the kidneys. PAGN, like urea, contains 2 moles of nitrogen and provides an alternate vehicle for waste nitrogen excretion.
Dosage forms of Glycerol Phenylbutyrate
Glyceryl Tri-4-Phenylbutyrate GPB
Horizon Therapeutics, Llc.
Humans and other mammals
Indication of Glycerol Phenylbutyrate
Glycerol phenylbutyrate is a nitrogen-binding agent for the chronic management of adult and pediatric patients 2 years of age with urea cycle disorders (UCDs) who cannot be managed by dietary protein restriction and/or amino acid supplementation alone.
Toxicity of Glycerol Phenylbutyrate
Most common adverse reactions in 10% of patients are diarrhea, flatulence, and headache.
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