Save up -80% on Glycopyrronium
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2018 Price of Glycopyrronium
Robinul 0.2 mg/ml vial
* price without discount in nearest pharmacy. Price may vary.
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Glycopyrronium volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Glycopyrronium
Glycopyrronium (as the bromide salt glycopyrrolate) is a synthetic anticholinergic agent with a quaternary ammonium structure. A muscarinic competitive antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics. In October 2015, glycopyrrolate was approved by the FDA for use as a standalone treatment for Chronic obstructive pulmonary disease (COPD), as Seebri Neohaler.
Glycopyrronium mechanism of action
Glycopyrrolate binds competitively to the muscarinic acetylcholine receptor. Like other anticholinergic (antimuscarinic) agents, it inhibits the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These peripheral cholinergic receptors are present in the autonomic effector cells of smooth muscle, cardiac muscle, the sinoatrial node, the atrioventricular node, exocrine glands and, to a limited degree, in the autonomic ganglia. Thus, it diminishes the volume and free acidity of gastric secretions and controls excessive pharyngeal, tracheal, and bronchial secretions.
Dosage forms of Glycopyrronium
|Aerosol, metered||respiratory (inhalation)|
|Inhalation powder, hard capsule||Inhalation use||44 micrograms|
Glycopyrrolate cation Glycopyrrolate ion
Astra Zeneca Pharmaceuticals Lp
Humans and other mammals
Indication of Glycopyrronium
For use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions, to reduce the volume and free acidity of gastric secretions and to block cardiac vagal inhibitory reflexes during induction of anesthesia and intubation. Also used to treat chronic obstructive pulmonary disease (COPD).
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