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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Gramicidin D

Neosporin gu irr 40 mg/ml amp

$23.12

ml

* price without discount in nearest pharmacy. Price may vary.

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Gramicidin D volume of distribution

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What is Gramicidin D

Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramcidins are 15 residue peptides with alternating D and L amino acids. The peptides assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a ?-helix. The helix itself is not long enough to span the membrane but it dimerizes to form the elongated channel needed to span the whole membrane. Gramicidin D is used primarily as a topical antibiotic and is one of the three constituents of consumer antibiotic polysporin ophthalmic solution.

Gramicidin D mechanism of action

Gramicidin D binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes). This results in membrane disruption and permeabilization (it acts as a channel). This leads to (i) loss of intracellular solutes (e.g., K+ and amino acids); (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in ATP pools; and (v) inhibition of DNA, RNA, and protein synthesis, which leads to cell death.

Dosage forms of Gramicidin D

FormRouteStrength
Solution/ dropsophthalmic
Solutionophthalmic
Liquidophthalmic
Prescription Generics

false

International Brands

Antibiotic Cream

Synonyms

Bacillus brevis gramicidin D Gramicidin

Manufacturers

Pharmetics (2011) Inc

CAS number

1405-97-6

UNII

5IE62321P4

State

liquid

Affected organisms

Pseudomonas aeruginosa

Indication of Gramicidin D

For treatment of skin lesions, surface wounds and eye infections

Toxicity of Gramicidin D

RX24 Drugs Disclaimer: before buying a Gramicidin D on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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