Save up -80% on Granisetron
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Kytril
|$123.13||60 tablets/1 mg|
|price without discount in nearest pharmacy. Price may vary.|
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Granisetron volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Granisetron
A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Granisetron mechanism of action
Granisetron is a potent, selective antagonist of 5-HTsub3/sub receptors. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.
Dosage forms of Granisetron
|Injection, solution||intravenous||.1 mg/mL|
|Injection, solution||intravenous||1 mg/mL|
Humans and other mammals
Indication of Granisetron
For the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy (including high dose cisplatin), postoperation, and radiation (including total body irradiation and daily fractionated abdominal radiation).
Toxicity of Granisetron
LDsub50/sub gt;2000 mg/kg (rat, oral)
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