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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Granisetron

Granisetron hcl 0.1 mg/ml vial



* price without discount in nearest pharmacy. Price may vary.

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Granisetron volume of distribution

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What is Granisetron

A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.

Granisetron mechanism of action

Granisetron is a potent, selective antagonist of 5-HTsub3/sub receptors. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.

Dosage forms of Granisetron

Injection, solutionintravenous.1 mg/mL
Injection, solutionintravenous1 mg/mL
Injectionintravenous.1 mg/mL
Prescription Generics


International Brands



granisetron granisetron


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Granisetron

For the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy (including high dose cisplatin), postoperation, and radiation (including total body irradiation and daily fractionated abdominal radiation).

Toxicity of Granisetron

LDsub50/sub gt;2000 mg/kg (rat, oral)

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