Save up -80% on Grazoprevir

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Grazoprevir

$

* price without discount in nearest pharmacy. Price may vary.

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Grazoprevir volume of distribution

1250 L

About RX24Drugs

Discount Cards 16,000+

Clients Benefit 29%

Total savings $4,735,080

What is Grazoprevir

Grazoprevir is a second generation NS3/4a protease inhibitor approved for the treatment of hepatitis C virus (HCV) in combination with elbasvir as the fixed-dose combination product Zepatier (FDA). Use of this medication is indicated, with our without ribavirin, for the treatment of adults with HCV genotypes 1a, 1b, or 4. NS3/4a protease is an integral part of viral replication as it is responsible for cleaving the long polypeptide produced following translation of the viral genome. By inhibiting protease activity, grazoprevir prevents the formation of structural and nonstructural proteins required for replication and assembly (E1, E2, NS2, NS3, NS4A, NS4B, NS5A and NS5B).

Grazoprevir mechanism of action

Grazaprevir is a second generation NS3/4a protease inhibitor use to inhibit viral HCV replication. NS3/4a protease is an integral part of viral replication as it is responsible for cleaving the long polypeptide produced following translation of the viral genome. By inhibiting protease activity, grazoprevir prevents the formation of structural and nonstructural proteins required for replication and assembly (E1, E2, NS2, NS3, NS4A, NS4B, NS5A and NS5B).

Dosage forms of Grazoprevir

FormRouteStrength
Tabletoral
Tablet, film coatedoral
Prescription Generics

false

International Brands

Zepatier

Synonyms

(1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropanesulfonyl)carbamoyl]-2-ethenylcyclopropyl}-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide Grazoprevir

Manufacturers

Merck Canada Inc

CAS number

1350514-68-9

UNII

8YE81R1X1J

State

solid

Affected organisms

Hepatitis C virus, RSV and other RNA/DNA viruses

Indication of Grazoprevir

Grazoprevir is indicated in combination with elbasvir (as the fixed dose combination product Zepatier) with or without ribavirin for treatment of chronic HCV genotypes 1a, 1b, or 4 infection in adults.

Toxicity of Grazoprevir

The most commonly reported adverse reactions of all intensity (greater than or equal to 5% in placebo-controlled trials) were fatigue, headache, anemia, and nausea.

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