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Price of Griseofulvin
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Griseofulvin volume of distribution
What is Griseofulvin
An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. (PubChem)
Griseofulvin mechanism of action
Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis.
Dosage forms of Griseofulvin
|Tablet, film coated||oral||125 mg/1|
|Tablet, film coated||oral||250 mg/1|
Fulvicin Pg Tab 330mg
Schering Plough Canada Inc
Yeast and other Trichophyton or Microsporum fungi
Indication of Griseofulvin
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by iTrichophyton /i or iMicrosporum /i fungi.
Toxicity of Griseofulvin
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
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