Save up -80% on Guanfacine

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Guanfacine

Guanfacine 2 mg tablet



* price without discount in nearest pharmacy. Price may vary.

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Guanfacine volume of distribution

* 6.3 L/kg

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What is Guanfacine

A centrally acting antihypertensive agent. The drug lowers both systolic and diastolic blood pressure by activating the central nervous system alpha-2 adrenoreceptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation.

Guanfacine mechanism of action

Guanfacine selectively stimulates central alpha(2)-adrenergic receptors, resulting in inhibition of sympathetic vasomotor centers, which contributes predominantly to the hypotensive effects of the drug. Central effects of guanfacine lead to reduced peripheral sympathetic nerve impulses from the vasomotor center to the heart and blood vessels. This results in a decrease in peripheral vascular resistance and a reduction in heart rate. The stimulation of peripheral alpha(2)-adrenergic receptors may also contribute to hypotensive effects.

Dosage forms of Guanfacine

Tabletoral1 mg/1
Tabletoral2 mg/1
Tablet, extended releaseoral1 mg/1
Prescription Generics


International Brands



Estulic Guanfacina


Epic Pharma, LLC

CAS number






Affected organisms

Humans and other mammals

Indication of Guanfacine

For use alone or in combination with other classes of antihypertensive agents in the management of hypertension. Has also been used for the treatment of attention deficit hyperactivity disorder (ADHD) in pediatric patients.

Toxicity of Guanfacine

Symptoms of overdose include drowsiness, lethargy, bradycardia and hypotension. LD sub 50 /sub =165mg/kg (orally in mice)

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