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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Guanidine

Guanidine hcl 125 mg tablet

$0.25

tablet

* price without discount in nearest pharmacy. Price may vary.

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Guanidine volume of distribution

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What is Guanidine

A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.

Guanidine mechanism of action

Dosage forms of Guanidine

FormRouteStrength
Tabletoral125 mg/1
Prescription Generics

false

International Brands

Guanidine Hydrochloride

Synonyms

Aminomethanamidine Gu

Manufacturers

Merck Sharp Dohme Corp.

CAS number

113-00-8

UNII

JU58VJ6Y3B

State

solid

Affected organisms

Humans and other mammals

Indication of Guanidine

For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.

Toxicity of Guanidine

LD sub50 /sub = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.

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