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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Haloperidol

Haloperidol 10 mg tablet

$1.46

tablet

* price without discount in nearest pharmacy. Price may vary.

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What is Haloperidol

A phenyl-piperidinyl-butyrophenone that is used primarily to treat schizophrenia and other psychoses. It is also used in schizoaffective disorder, delusional disorders, ballism, and tourette syndrome (a drug of choice) and occasionally as adjunctive therapy in mental retardation and the chorea of huntington disease. It is a potent antiemetic and is used in the treatment of intractable hiccups. (From AMA Drug Evaluations Annual, 1994, p279)

Haloperidol mechanism of action

The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known, but the drug appears to depress the CNS at the subcortical level of the brain, midbrain, and brain stem reticular formation. Haloperidol seems to inhibit the ascending reticular activating system of the brain stem (possibly through the caudate nucleus), thereby interrupting the impulse between the diencephalon and the cortex. The drug may antagonize the actions of glutamic acid within the extrapyramidal system, and inhibitions of catecholamine receptors may also contribute to haloperidol’s mechanism of action. Haloperidol may also inhibit the reuptake of various neurotransmitters in the midbrain, and appears to have a strong central antidopaminergic and weak central anticholinergic activity. The drug produces catalepsy and inhibits spontaneous motor activity and conditioned avoidance behaviours in animals. The exact mechanism of antiemetic action of haloperidol has also not been fully determined, but the drug has been shown to directly affect the chemoreceptor trigger zone (CTZ) through the blocking of dopamine receptors in the CTZ.

Dosage forms of Haloperidol

FormRouteStrength
Liquidoral2 mg
Tabletoral.5 mg
Tabletoral1 mg
Prescription Generics

true

International Brands

Apo Haloperidol Liq 2mg/ml

Synonyms

1-(3-P-Fluorobenzoylpropyl)-4-P-chlorophenyl-4-hydroxypiperidine 4-(4-(Para-chlorophenyl)-4-hydroxypiperidino)-4′-fluorobutyrophenone

Manufacturers

Apotex Inc

CAS number

52-86-8

UNII

J6292F8L3D

State

solid

Affected organisms

Humans and other mammals

Indication of Haloperidol

For the management of psychotic disorders (eg. schizophrenia) and delirium, as well as to control tics and vocal utterances of Tourette’s syndrome (Gilles de la Tourette’s syndrome). Also used for the treatment of severe behavioural problems in children with disrubtive behaviour disorder or ADHD (attention-deficit hyperactivity disorder). Haloperidol has been used in the prevention and control of severe nausea and vomiting.

Toxicity of Haloperidol

LD sub50 /sub=165 mg/kg (rats, oral)

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