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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Hydralazine

HydrALAZINE HCl 100 mg tablet

$1.05

tablet

* price without discount in nearest pharmacy. Price may vary.

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Hydralazine volume of distribution

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What is Hydralazine

A direct-acting vasodilator that is used as an antihypertensive agent.

Hydralazine mechanism of action

Although the precise mechanism of action of hydralazine is not fully understood, the major effects are on the cardiovascular system. Hydralazine apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. It has also been suggested that cyclic 3′,5′-adenosine monophosphate (cyclic AMP) mediates, at least partly, the relaxation of arterial smooth muscle by altering cellular calcium metabolism, which interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state. In hypertensive patients, the hydralazine-induced decrease in blood pressure is accompanied by increased heart rate, cardiac output, and stroke volume, probably because of a reflex response to decreased peripheral resistance. The drug has no direct effect on the heart. Hydralazine may increase pulmonary arterial pressure, as well as coronary, splanchnic, cerebral, and renal blood flow. The preferential dilatation of arterioles, as compared to veins, minimizes postural hypotension and promotes the increase in cardiac output. Hydralazine usually increases renin activity in plasma, presumably as a result of increased secretion of renin by the renal juxtaglomerular cells in response to reflex sympathetic discharge. This increase in renin activity leads to the production of angiotensin II, which then causes stimulation of aldosterone and consequent sodium reabsorption. Tolerance to the antihypertensive effect of the drug develops during prolonged therapy, especially if a diuretic is not administered concurrently. In patients with CHF, hydralazine decreases systemic vascular resistance and increases cardiac output.

Dosage forms of Hydralazine

FormRouteStrength
Solutionintravenous20 mg
Tablet, film coatedoral
Tabletoral10 mg
Prescription Generics

false

International Brands

Apresoline

Synonyms

(1Z)-1(2H)-Phthalazinone hydrazone (2H)-Phthalazinone hydrazone

Manufacturers

Sterimax Inc

CAS number

86-54-4

UNII

26NAK24LS8

State

solid

Affected organisms

Humans and other mammals

Indication of Hydralazine

For the treatment of essential hypertension, alone or as an adjunct. Also for the management of severe hypertension when the drug cannot be given orally or when blood pressure must be lowered immediately, congestive heart failure (in combination with cardiac glycosides and diuretics and/or with isosorbide dinitrate), and hypertension secondary to pre-eclampsia/eclampsia.

Toxicity of Hydralazine

Oral LD50 in rats: 173 and 187 mg/kg

RX24 Drugs Disclaimer: before buying a Hydralazine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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