Save up -80% on Hydrochlorothiazide

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Microzide

$4.130 tablets/25 mg
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We offer free Hydrochlorothiazide coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Hydrochlorothiazide every time. What are you waiting for? Claim your prescription drug card now!

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Hydrochlorothiazide volume of distribution

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Hydrochlorothiazide

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.

Hydrochlorothiazide mechanism of action

Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Normally, the sodium-chloride symporter transports sodium and chloride from the lumen into the epithelial cell lining the distal convoluted tubule. The energy for this is provided by a sodium gradient established by sodium-potassium ATPases on the basolateral membrane. Once sodium has entered the cell, it is transported out into the basolateral interstitium via the sodium-potassium ATPase, causing an increase in the osmolarity of the interstitium, thereby establishing an osmotic gradient for water reabsorption. By blocking the sodium-chloride symporter, hydrochlorothiazide effectively reduces the osmotic gradient and water reabsorption throughout the nephron.

Dosage forms of Hydrochlorothiazide

FormRouteStrength
TabletOral use
Tablet, coatedoral
Capsuleoral12.5 mg/1

Prescription Generics

false

International Brands

Accuretic

Synonyms

Esidrix HCTZ

Manufacturers

Parke Davis Div Of Pfizer Inc

CAS number

58-93-5

UNII

0J48LPH2TH

State

solid

Affected organisms

Humans and other mammals

Indication of Hydrochlorothiazide

For the treatment of high blood pressure and management of edema.

Toxicity of Hydrochlorothiazide

The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. The oral LD50 of hydrochlorothiazide is greater than 10 g/kg in the mouse and rat.

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