Save up -80% on Hydrocodone

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
Pharmacists and Patients support.

2019 Price of Zohydro ER

$558.160 capsules/10 mg
price without discount in nearest pharmacy. Price may vary.

Claim your free Hydrocodone discount card

We offer free Hydrocodone coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Hydrocodone every time. What are you waiting for? Claim your prescription drug card now!

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Hydrocodone volume of distribution

The volume of distribution of hydrocodone is 3.3 to 4.7 L/kg. The plasma protein binding of hydrocodone is 20 to 50%.

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About RX24Drugs

2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Hydrocodone

Narcotic analgesic related to codeine, but more potent and more addicting by weight. It is used also as cough suppressant.

Hydrocodone mechanism of action

Hydrocodone acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Hydrocodone primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as hydrocodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Dosage forms of Hydrocodone

FormRouteStrength
Liquidoral
Syruporal1 mg
Tabletoral5 mg

Prescription Generics

false

International Brands

Caldomine Dh Adulte

Synonyms

(-)-Dihydrocodeinone 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one

Manufacturers

Technilab Pharma Inc.

CAS number

125-29-1

UNII

6YKS4Y3WQ7

State

solid

Affected organisms

Humans and other mammals

Indication of Hydrocodone

For relief of moderate to moderately severe pain. Also used for the symptomatic relief of nonproductive cough, alone or in combination with other antitussives or expectorants.

Toxicity of Hydrocodone

Symptoms of overdose include respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, dizziness, ringing in the ears, confusion, blurred vision, eye problems, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdose, apnea, circulatory collapse, cardiac arrest and death may occur. LD sub 50 /sub =85.7mg/kg (subcutaneous, in mice).

RX24 Drugs Disclaimer: before buying a Hydrocodone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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