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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Hydrocodone

Hydrocodone-Acetaminophen 10-750 mg tablet

$1.1

tablet

* price without discount in nearest pharmacy. Price may vary.

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Hydrocodone volume of distribution

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What is Hydrocodone

Narcotic analgesic related to codeine, but more potent and more addicting by weight. It is used also as cough suppressant.

Hydrocodone mechanism of action

Hydrocodone acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Hydrocodone primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as hydrocodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Dosage forms of Hydrocodone

FormRouteStrength
Liquidoral
Syruporal1 mg
Tabletoral5 mg
Prescription Generics

false

International Brands

Caldomine Dh Adulte

Synonyms

(-)-Dihydrocodeinone 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one

Manufacturers

Technilab Pharma Inc.

CAS number

125-29-1

UNII

6YKS4Y3WQ7

State

solid

Affected organisms

Humans and other mammals

Indication of Hydrocodone

For relief of moderate to moderately severe pain. Also used for the symptomatic relief of nonproductive cough, alone or in combination with other antitussives or expectorants.

Toxicity of Hydrocodone

Symptoms of overdose include respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, dizziness, ringing in the ears, confusion, blurred vision, eye problems, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdose, apnea, circulatory collapse, cardiac arrest and death may occur. LD sub 50 /sub =85.7mg/kg (subcutaneous, in mice).

RX24 Drugs Disclaimer: before buying a Hydrocodone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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