Save up -80% on Hydrocortisone
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Cortef
|$21.03||90 tablets/10 mg|
|price without discount in nearest pharmacy. Price may vary.|
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Hydrocortisone volume of distribution
Hydrocortisone concentrations were measured in plasma and saliva. After IV administration, hydrocortisone was eliminated with a total body clearance of 18 L/hr and a half-life of 1.7 hr. The volume of distribution was 34 L. Oral bioavailability averaged 96%.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Hydrocortisone
The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Hydrocortisone mechanism of action
Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In other words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Dosage forms of Hydrocortisone
|Emocort Cream||1%||45g Cream||$39.00|
|Emocort Cream||2.50%||45g Cream||$41.50|
|Barriere HC Cream||1%||45g Cream||$47.50|
|Emocort Lotion||1%||60mL Lotion||$41.50|
|Prevex HC||0.10%||30g Cream||$36.60|
|Hydrocortisone 17 Valerate||0.20%||60g Cream||$64.00|
|Hydrocortisone 17 Valerate||0.20%||45g Ointment||$51.00|
|Anusol HC Ointment||0.5/0.5%||30g Ointment||$55.00|
|Anusol HC Suppository||10/10mg||72 Suppository||$184.00|
|Proctofoam HC||1%||44.8g Foam||$106.00|
|Cortate Cream||0.50%||15g Cream (PMS)||$16.20|
|Cortifoam Rectal Foam||10%||30g Foam||$242.00|
|Vioform Hydrocortisone Cream||3mg/1%||30g Cream||$57.00|
|Cipro HC Otic||0.2/1%||10mL Liquid suspension||$52.00|
1 Hydrocortisone Maximum Strength
American Sales Company
Humans and other mammals
Indication of Hydrocortisone
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn’s disease.
Toxicity of Hydrocortisone
Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing
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