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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Cortef

$21.0390 tablets/10 mg
Price with discount in nearest pharmacy. Price may vary.

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Hydrocortisone volume of distribution

Hydrocortisone concentrations were measured in plasma and saliva. After IV administration, hydrocortisone was eliminated with a total body clearance of 18 L/hr and a half-life of 1.7 hr. The volume of distribution was 34 L. Oral bioavailability averaged 96%.

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What is Hydrocortisone

The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

Hydrocortisone mechanism of action

Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In other words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

Dosage forms of Hydrocortisone

Emocort Cream1%45g Cream$39.00
Emocort Cream2.50%45g Cream$41.50
Cortef10mg100 Tablet$45.00
Cortef20mg100 Tablet$59.00
Hydrocortisone1%15g Cream$27.50
Barriere HC Cream1%45g Cream$47.50
Emocort Lotion1%60mL Lotion$41.50
Prevex HC0.10%30g Cream$36.60
Hydrocortisone 17 Valerate0.20%60g Cream$64.00
Hydrocortisone 17 Valerate0.20%45g Ointment$51.00
Anusol HC Ointment0.5/0.5%30g Ointment$55.00
Anusol HC Suppository10/10mg72 Suppository$184.00
Proctofoam HC1%44.8g Foam$106.00
Cortate Cream0.50%15g Cream (PMS)$16.20
Cortifoam Rectal Foam10%30g Foam$242.00
Locoid Lipocream0.1%60g$100.00
Vioform Hydrocortisone Cream3mg/1%30g Cream$57.00
Cipro HC Otic0.2/1%10mL Liquid suspension$52.00
Xerese5/1%5g Cream$66.00

Prescription Generics


International Brands

1 Hydrocortisone Maximum Strength


(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione (11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione


American Sales Company

CAS number






Affected organisms

Humans and other mammals

Indication of Hydrocortisone

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn’s disease.

Toxicity of Hydrocortisone

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

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