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Price of Hydromorphone
Dilaudid 2 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Hydromorphone volume of distribution
What is Hydromorphone
An opioid analgesic derived from morphine and used mainly as an analgesic. It has a shorter duration of action and is more potent than morphine. (PubChem)
Hydromorphone mechanism of action
Hydromorphone is a narcotic analgesic; its principal therapeutic effect is relief of pain. Hydromorphone interacts predominantly with the opioid mu-receptors. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, Hydromorphone exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Hydromorphone also binds with kappa-receptors which are thought to mediate spinal analgesia, miosis and sedation.
Dosage forms of Hydromorphone
|Liquid||intramuscular; intravenous; subcutaneous||2 mg|
Humans and other mammals
Indication of Hydromorphone
For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, or burns.
Toxicity of Hydromorphone
Hydromorphone is a schedule II narcotic which can lead to physical dependence or addiction. High doses lead to respiratory depression, nausea, and vomiting. Overdoses lead to extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur.
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