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Price of Hydroxocobalamin
Hydroxocobalamin 1000 mcg/ml
* price without discount in nearest pharmacy. Price may vary.
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Hydroxocobalamin volume of distribution
What is Hydroxocobalamin
Injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency. (PubChem)
Hydroxocobalamin mechanism of action
Vitamin B12 exists in four major forms referred to collectively as cobalamins; deoxyadenosylcobalamin, methylcobalamin, hydroxocobalamin, and cyanocobalamin. Two of these, methylcobalamin and 5-deoxyadenosyl cobalamin, are primarily used by the body. Methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.
Dosage forms of Hydroxocobalamin
|Injection, powder, lyophilized, for solution||intravenous||2.5 g/100mL|
|Injection, powder, lyophilized, for solution||intravenous||5 g/250mL|
|Powder for solution||intravenous||2.5 g|
Emd Serono A Division Of Emd Inc Canada
Humans and other mammals
Indication of Hydroxocobalamin
For treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets or other restrictive diets. Also for the treatment of known or suspected cyanide poisoning.
Toxicity of Hydroxocobalamin
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