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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Plaquenil

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We offer free Hydroxychloroquine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Hydroxychloroquine every time. What are you waiting for? Claim your prescription drug card now!

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What is Hydroxychloroquine

A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites.

Hydroxychloroquine mechanism of action

Although the exact mechanism of action is unknown, it may be based on ability of hydroxychloroquine to bind to and alter DNA. Hydroxychloroquine has also has been found to be taken up into the acidic food vacuoles of the parasite in the erythrocyte. This increases the pH of the acid vesicles, interfering with vesicle functions and possibly inhibiting phospholipid metabolism. In suppressive treatment, hydroxychloroquine inhibits the erythrocytic stage of development of plasmodia. In acute attacks of malaria, it interrupts erythrocytic schizogony of the parasite. Its ability to concentrate in parasitized erythrocytes may account for their selective toxicity against the erythrocytic stages of plasmodial infection. As an antirheumatic, hydroxychloroquine is thought to act as a mild immunosuppressant, inhibiting the production of rheumatoid factor and acute phase reactants. It also accumulates in white blood cells, stabilizing lysosomal membranes and inhibiting the activity of many enzymes, including collagenase and the proteases that cause cartilage breakdown.

Dosage forms of Hydroxychloroquine

FormRouteStrength
Tablet, coatedoral200 mg/1
Tablet, film coatedenteral200 mg/1
Tabletoral200 mg/1

Prescription Generics

true

International Brands

Apo-hydroxyquine

Synonyms

(+-)-Hydroxychloroquine ( -hydroxychloroquine

Manufacturers

Apotex Inc

CAS number

118-42-3

UNII

4QWG6N8QKH

State

solid

Affected organisms

Plasmodium

Indication of Hydroxychloroquine

For the suppressive treatment and treatment of acute attacks of malaria due to iPlasmodium vivax/i, iP. malariae/i, iP. ovale/i, and susceptible strains of iP. falciparum/i. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis.

Toxicity of Hydroxychloroquine

Symptoms of overdose include headache, drowsiness, visual disturbances, cardiovascular collapse, and convulsions, followed by sudden and early respiratory and cardiac arrest. The electrocardiogram may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, and progressive bradycardia leading to ventricular fibrillation and/or arrest.

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