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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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Hydroxychloroquine volume of distribution

Plasma concentrations were analyzed by noncompartmental and mixed-effect modeling approaches. A two-compartment model with first-order absorption best described the data. The clearance and the central and peripheral volumes of distribution were 15.5 liters/h, 733 liters, and 1,630 liters, respectively. We measured the plasma concentrations of HCQ in patients with prophylactic failure of HCQ and compared them with the prediction intervals of the simulated concentrations for HCQ from the final PK model built in this study.

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What is Hydroxychloroquine

A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites.

Hydroxychloroquine mechanism of action

Although the exact mechanism of action is unknown, it may be based on ability of hydroxychloroquine to bind to and alter DNA. Hydroxychloroquine has also has been found to be taken up into the acidic food vacuoles of the parasite in the erythrocyte. This increases the pH of the acid vesicles, interfering with vesicle functions and possibly inhibiting phospholipid metabolism. In suppressive treatment, hydroxychloroquine inhibits the erythrocytic stage of development of plasmodia. In acute attacks of malaria, it interrupts erythrocytic schizogony of the parasite. Its ability to concentrate in parasitized erythrocytes may account for their selective toxicity against the erythrocytic stages of plasmodial infection. As an antirheumatic, hydroxychloroquine is thought to act as a mild immunosuppressant, inhibiting the production of rheumatoid factor and acute phase reactants. It also accumulates in white blood cells, stabilizing lysosomal membranes and inhibiting the activity of many enzymes, including collagenase and the proteases that cause cartilage breakdown.

Dosage forms of Hydroxychloroquine

Tablet, coatedoral200 mg/1
Tablet, film coatedenteral200 mg/1
Tabletoral200 mg/1

Prescription Generics


International Brands



(+-)-Hydroxychloroquine ( -hydroxychloroquine


Apotex Inc

CAS number






Affected organisms


Indication of Hydroxychloroquine

For the suppressive treatment and treatment of acute attacks of malaria due to iPlasmodium vivax/i, iP. malariae/i, iP. ovale/i, and susceptible strains of iP. falciparum/i. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis.

Toxicity of Hydroxychloroquine

Symptoms of overdose include headache, drowsiness, visual disturbances, cardiovascular collapse, and convulsions, followed by sudden and early respiratory and cardiac arrest. The electrocardiogram may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, and progressive bradycardia leading to ventricular fibrillation and/or arrest.

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