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Price of Hydroxyzine
Hydroxyzine hcl 50 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Hydroxyzine volume of distribution
What is Hydroxyzine
A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. (PubChem)
Hydroxyzine mechanism of action
Hydroxyzine competes with histamine for binding at H sub1 /sub-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of hydroxyzine occur at the subcortical level of the CNS. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic.
Dosage forms of Hydroxyzine
Apo Hydroxyzine Cap 10mg
Humans and other mammals
Indication of Hydroxyzine
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Toxicity of Hydroxyzine
Oral, rat LD sub50 /sub: 950 mg/kg. Symptoms of overexposure include hypersedation.
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