Save up -80% on Ibandronate
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2018 Price of Ibandronate
Boniva 2.5 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Ibandronate volume of distribution
* 90 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ibandronate
Ibandronate is a nitrogen-containing bisphosphonate in the same class as alendronate and risedronate. Ibandronate inhibits osteoclast-mediated bone resorption. All of the bisphosphonates prevent the breakdown of bone by bone cells called osteoclasts. In persons who are at high risk for osteoporosis, bisphosphonates not only result in increased amounts of bone and bone strength, they also reduce the risk of hip fractures and other bone fractures.
Ibandronate mechanism of action
The action of ibandronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting farnesyl pyrophosphate (FPP) synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.
Dosage forms of Ibandronate
|Ibandronate Sodium||3mg/3ml||1 Injection||$76.00|
|Ibandronate Sodium||3mg/3ml||10 Injection||$541.40|
|Ibandronate Sodium||150mg||3 Tablet||$26.00|
|Boniva Injection||3mg/3ml||1 Injection||$498.40|
Bondronat Ibandronic Acid
Hoffmann La Roche Limited
Humans and other mammals
Indication of Ibandronate
For the treatment and prevention of osteoporosis in postmenopausal women.
Toxicity of Ibandronate
LD sub50 /sub = 811 mg/kg (rat, oral), side effects include bronchitis, pneumonia and urinary tract infections.
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