Save up -80% on Ibandronate
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Boniva
|$575.51||1 dose pack (3 tablets) 150mg|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Boniva coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Ibandronate every time. What are you waiting for? Claim your prescription drug card now!
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Ibandronate volume of distribution
90 L. Poorly absorbed (mean bioavailability following a 2.5 mg oral dose is about 0.6% compared to intravenous dosing). Absorption is impaired by any kind of food or drink other than plain water.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ibandronate
Ibandronate is a nitrogen-containing bisphosphonate in the same class as alendronate and risedronate. Ibandronate inhibits osteoclast-mediated bone resorption. All of the bisphosphonates prevent the breakdown of bone by bone cells called osteoclasts. In persons who are at high risk for osteoporosis, bisphosphonates not only result in increased amounts of bone and bone strength, they also reduce the risk of hip fractures and other bone fractures.
Ibandronate mechanism of action
The action of ibandronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting farnesyl pyrophosphate (FPP) synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.
Dosage forms of Ibandronate
|Ibandronate Sodium||3mg/3ml||1 Injection||$76.00|
|Ibandronate Sodium||3mg/3ml||10 Injection||$541.40|
|Ibandronate Sodium||150mg||3 Tablet||$26.00|
|Boniva Injection||3mg/3ml||1 Injection||$498.40|
Bondronat Ibandronic Acid
Hoffmann La Roche Limited
Humans and other mammals
Indication of Ibandronate
For the treatment and prevention of osteoporosis in postmenopausal women.
Toxicity of Ibandronate
LD sub50 /sub = 811 mg/kg (rat, oral), side effects include bronchitis, pneumonia and urinary tract infections.
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