Save up -80% on Ibandronate

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Ibandronate

Boniva 2.5 mg tablet

$4.16

tablet

* price without discount in nearest pharmacy. Price may vary.

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Ibandronate volume of distribution

* 90 L

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What is Ibandronate

Ibandronate is a nitrogen-containing bisphosphonate in the same class as alendronate and risedronate. Ibandronate inhibits osteoclast-mediated bone resorption. All of the bisphosphonates prevent the breakdown of bone by bone cells called osteoclasts. In persons who are at high risk for osteoporosis, bisphosphonates not only result in increased amounts of bone and bone strength, they also reduce the risk of hip fractures and other bone fractures.

Ibandronate mechanism of action

The action of ibandronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting farnesyl pyrophosphate (FPP) synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Dosage forms of Ibandronate

DrugDosageQuantityPrice
Ibandronate Sodium3mg/3ml1 Injection$76.00
Ibandronate Sodium3mg/3ml10 Injection$541.40
Ibandronate Sodium150mg3 Tablet$26.00
Boniva Injection3mg/3ml1 Injection$498.40
Boniva150mg3 Tablet$127.50
Prescription Generics

false

International Brands

Bondronat

Synonyms

Bondronat Ibandronic Acid

Manufacturers

Hoffmann La Roche Limited

CAS number

114084-78-5

UNII

UMD7G2653W

State

solid

Affected organisms

Humans and other mammals

Indication of Ibandronate

For the treatment and prevention of osteoporosis in postmenopausal women.

Toxicity of Ibandronate

LD sub50 /sub = 811 mg/kg (rat, oral), side effects include bronchitis, pneumonia and urinary tract infections.

RX24 Drugs Disclaimer: before buying a Ibandronate on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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