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Price of Ibutilide
Ibutilide fum 1 mg/10 ml vial
* price without discount in nearest pharmacy. Price may vary.
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Ibutilide volume of distribution
* 11 L/kg
What is Ibutilide
Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm.
Ibutilide mechanism of action
Ibutilide is a ‘pure’ class III antiarrhythmic drug, used intravenously against atrial flutter and fibrillation. At a cellular level it exerts two main actions: induction of a persistent Na+ current sensitive to dihydropyridine Ca sup 2+ /sup channel blockers and potent inhibition of the cardiac rapid delayed rectifier K sup + /sup current, by binding within potassium channel pores. In other words, Ibutilide binds to and alters the activity of hERG potassium channels, delayed inward rectifier potassium (IKr) channels and L-type (dihydropyridine sensitive) calcium channels
Dosage forms of Ibutilide
|Injection, solution||intravenous||.1 mg/mL|
Pharmacia and Upjohn Company
Humans and other mammals
Indication of Ibutilide
Indicated for the rapid conversion of atrial fibrillation or atrial flutter of recent onset to sinus rhythm.
Toxicity of Ibutilide
Acute overdose in animals results in CNS toxicity; notably, CNS depression, rapid gasping breathing, and convulsions. The intravenous median lethal dose in the rat was more than 50 mg/kg which is, on a mg/m sup 2 /sup basis, at least 250 times the maximum recommended human dose.
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