Save up -80% on Icatibant

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Firazyr

$32,853.793 cartons (1 syringe) 30mg/3ml
price without discount in nearest pharmacy. Price may vary.

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We offer free Icatibant coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Icatibant every time. What are you waiting for? Claim your prescription drug card now!

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Icatibant volume of distribution

Volume of distribution at steady state of 29.0 ± 8.7 L

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About RX24Drugs

2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Icatibant

Icatibant (Firazyr) is a synthetic peptidomimetic drug consisting of ten amino acids, and acts as an effective and specific antagonist of bradykinin B2 receptors. It has been approved in the EU for use in hereditary angioedema, and is under investigation for a number of other conditions in which bradykinin is thought to play a significant role. Icatibant currently has orphan drug status in the United States and FDA approved on August 25, 2011.

Icatibant mechanism of action

Bradykinin is a peptide-based hormone that is formed locally in tissues, very often in response to a trauma. It increases vessel permeability, dilates blood vessels and causes smooth muscle cells to contract. Bradykinin plays an important role in the mediation of pain. Surplus bradykinin is responsible for the typical symptoms of inflammation, such as swelling, redness, overheating and pain. These symptoms are mediated by activation of bradykinin B2 receptors. In patients with HAE, they have an absent or dysfunctional C1-esterase inhibitor. This inhibitor is responsible for the production of bradykinin in which displacement of bradykinin from B2 receptors by icatibant has an inhibitory effect on the receptor for a relatively long time.

Dosage forms of Icatibant

FormRouteStrength
Injection, solutionsubcutaneous30 mg/3mL
Solutionsubcutaneous10 mg

Prescription Generics

false

International Brands

Firazyr

Synonyms

HOE 140

Manufacturers

Shire US Manufacturing Inc.

CAS number

130308-48-4

UNII

7PG89G35Q7

State

solid

Affected organisms

Humans and other mammals

Indication of Icatibant

Approved for use in acute attacks of hereditary angioedema (HAE). Investigated for use/treatment in angioedema, liver disease, and burns and burn infections.

Toxicity of Icatibant

Approved for use in acute attacks of hereditary angioedema (HAE). Investigated for use/treatment in angioedema, liver disease, and burns and burn infections. Icatibant is a potent, specific, competitive, and selective peptidomimetic bradykinin beta2-receptor antagonist (pA2 = 9.04).

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Icatibant on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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