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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Icosapent ethyl

$

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Icosapent ethyl volume of distribution

Steady state volume of distribution of active EPA is 88 L

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What is Icosapent ethyl

Icosapent ethyl or ethyl eicosapentaenoic acid is a synthetic derivative of the omega-3 fatty acid eicosapentaenoic acid (EPA). It is used as adjunct therapy for severe hypertriglyceridemia (TG levels 500 mg/dL). FDA approved on July 26, 2012.

Icosapent ethyl mechanism of action

Studies suggest that EPA reduces hepatic very low-density lipoprotein triglycerides (VLDL-TG) synthesis and/or secretion and enhances TG clearance from circulating VLDL particles. Potential mechanisms of action include increased -oxidation; inhibition of acyl-CoA:1,2-diacylglycerol acyltransferase (DGAT); decreased lipogenesis in the liver; and increased plasma lipoprotein lipase activity.

Dosage forms of Icosapent ethyl

FormRouteStrength
Capsuleoral1000 mg/1
Capsuleoral500 mg/1
Prescription Generics

false

International Brands

Vascepa

Synonyms

EPA ethyl ester Epadel S

Manufacturers

Amarin Pharma Inc.

CAS number

86227-47-6

UNII

6GC8A4PAYH

State

solid

Affected organisms

Humans and other mammals

Indication of Icosapent ethyl

Icosapent ethyl is used as adjunct therapy to reduce triglyceride (TG) levels in adults with severe (500 mg/dL) hypertriglyceridemia.

Toxicity of Icosapent ethyl

Icosapent ethyl is generally well tolerated and adverse effects are unrelated to treatment.

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