Save up -80% on Icosapent ethyl
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2018 Price of Icosapent ethyl
* price without discount in nearest pharmacy. Price may vary.
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Icosapent ethyl volume of distribution
Steady state volume of distribution of active EPA is 88 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Icosapent ethyl
Icosapent ethyl or ethyl eicosapentaenoic acid is a synthetic derivative of the omega-3 fatty acid eicosapentaenoic acid (EPA). It is used as adjunct therapy for severe hypertriglyceridemia (TG levels 500 mg/dL). FDA approved on July 26, 2012.
Icosapent ethyl mechanism of action
Studies suggest that EPA reduces hepatic very low-density lipoprotein triglycerides (VLDL-TG) synthesis and/or secretion and enhances TG clearance from circulating VLDL particles. Potential mechanisms of action include increased -oxidation; inhibition of acyl-CoA:1,2-diacylglycerol acyltransferase (DGAT); decreased lipogenesis in the liver; and increased plasma lipoprotein lipase activity.
Dosage forms of Icosapent ethyl
EPA ethyl ester Epadel S
Amarin Pharma Inc.
Humans and other mammals
Toxicity of Icosapent ethyl
Icosapent ethyl is generally well tolerated and adverse effects are unrelated to treatment.
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