Save up -80% on Immune Globulin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Hizentra
|$178.18||1 vial (5ml) 1g|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Hizentra coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Immune Globulin every time. What are you waiting for? Claim your prescription drug card now!
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Immune Globulin volume of distribution
The maximum IgA content is 50 micrograms/ml. Produced from the plasma of human donors. Excipients with known effects Hizentra contains approximately 250 mmol/L (range: 210 to 290) of L-proline.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Immune Globulin
Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human plasma via Cohn fractionation. The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ion exchange chromatography. IVIg contains the same distribution of IgG antibody subclasses as is found in the general human population. IgG subclasses are fully represented in the following proportions: 70.3% IgG1, 24.7% IgG2, 3.1% IgG3, and 1.9% IgG4. IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders.
Immune Globulin mechanism of action
IVIg interacts with a number of different components of the immune system, including cytokines, complement, Fc receptors and several cell surface immunocompetent molecules. IVIg also impacts different effector cells of the immune system (B and T lymphocytes, dendritic cells, etc.) and regulates a wide range of genes. Its main mechanism of actions are believed to be Fc-dependent and F(ab’)2-dependent. IVIg competitively blocks gamma Fc receptors, preventing the binding and ingestion of phagocytes and suppressing platelet depletion. IVIg contains a number of different antobodies, which prevent infection by attaching to the surface of invading pathogens and aiding in their disposal before they can infect cells. Antibodies remove pathogens via complement activation, agglutination or precipitation, pathogen receptor blocking, macrophage /tagging/ or neutralization (via binding) of pathogen toxins. Intact IVIg and F(ab?)2 fragments of IVIg can also neutralize the activity of various autoantibodies. By triggering the production of interleukin-1 receptor antagonist, IVIg modulates of the production of cytokines and cytokine antagonists. It also prevents the generation of the C5b-9 membrane attack complex and subsequent complement-mediated tissue damage by binding active complement components.
Dosage forms of Immune Globulin
|Injection, solution||intravenous||1 g/10mL|
|Injection, solution||intravenous||10 g/100mL|
|Injection, solution||intravenous||5 g/50mL|
Human IGG Human Immunoglobulin G
Kedrion Biopharma, Inc.
Humans and other mammals
Indication of Immune Globulin
IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders. These indications includes idiopathic thrombocytopenic purpura, Kawasaki disease, hypogammaglobulinemia, B cell chronic lymphocytic leukemia, bone marrow transplant complications, Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP), multiple sclerosis, rheumatoid arthritis, myesthenia gravis, Wiskott/Aldrich syndrome and inflammatory skin diseases.
Toxicity of Immune Globulin
No single-dose toxicity studies have been conducted with Hizentra. In general, single-dose toxicity studies may generate useful information on dose-response relationship early in drug development; however such information was considered to be broadly available for subcutaneous immunoglobulin (SCIG) products as well as for L-proline.
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