Save up -80% on Infliximab
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Price of Infliximab
Remicade 100 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Infliximab volume of distribution
What is Infliximab
Tumor necrosis factor (TNF-alpha) binding antibody (chimeric IgG1). It is composed of human constant and murine variable regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion
Infliximab mechanism of action
Infliximab neutralizes the biological activity of TNFa by binding with high affinity to the soluble and transmembrane forms of TNFa and inhibits binding of TNFa with its receptors. Infliximab does not neutralize TNFb (lymphotoxin a), a related cytokine that utilizes the same receptors as TNFa. TNFa activation normally induces the release of proinflammatory cytokines, the enhancement of leukocyte migration and activation of neutrophils among others. Neutralization of the biological activity of TNFa leads to an overall reduction in inflammation.
Dosage forms of Infliximab
|Powder for concentrate for solution for infusion||Intravenous use||100 mg|
|Injection, powder, lyophilized, for solution||intravenous||100 mg/10mL|
|Powder for solution||intravenous||100 mg|
Ig gamma-1 chain C region
Celltrion Healthcare Co Ltd
Humans and other mammals
Indication of Infliximab
To manage the signs and symptoms, as well as to induce and maintain clinical remission in adults with moderate to severe active Crohn’s disease or ulcerative colitis. Also used to manage signs and symptoms of rheumatoid arthritis (in conjunction with methotrexate), ankylosing spondylitis, psoriatic arthritis, and juvenile arthritis.
Toxicity of Infliximab
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