Save up -80% on Infliximab
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Remicade
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Remicade coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Infliximab every time. What are you waiting for? Claim your prescription drug card now!
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Infliximab volume of distribution
The volume of distribution of infliximab is low and at steady state ranges from 4.5 to 6 L. Therapeutic monoclonal antibodies, such as immunoglobulins, are cleared from the circulation primarily by catabolism. Median infliximab half-life is approximately 14 days.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Infliximab
Tumor necrosis factor (TNF-alpha) binding antibody (chimeric IgG1). It is composed of human constant and murine variable regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion
Infliximab mechanism of action
Infliximab neutralizes the biological activity of TNFa by binding with high affinity to the soluble and transmembrane forms of TNFa and inhibits binding of TNFa with its receptors. Infliximab does not neutralize TNFb (lymphotoxin a), a related cytokine that utilizes the same receptors as TNFa. TNFa activation normally induces the release of proinflammatory cytokines, the enhancement of leukocyte migration and activation of neutrophils among others. Neutralization of the biological activity of TNFa leads to an overall reduction in inflammation.
Dosage forms of Infliximab
|Powder for concentrate for solution for infusion||Intravenous use||100 mg|
|Injection, powder, lyophilized, for solution||intravenous||100 mg/10mL|
|Powder for solution||intravenous||100 mg|
Ig gamma-1 chain C region
Celltrion Healthcare Co Ltd
Humans and other mammals
Indication of Infliximab
To manage the signs and symptoms, as well as to induce and maintain clinical remission in adults with moderate to severe active Crohn’s disease or ulcerative colitis. Also used to manage signs and symptoms of rheumatoid arthritis (in conjunction with methotrexate), ankylosing spondylitis, psoriatic arthritis, and juvenile arthritis.
Toxicity of Infliximab
Furthermore, concurrent use of other immunosuppresive agents, such as 6-mercaptopurine, may reduce the incidence of less serious side effects, such as arthralgias, myopathies and other antibody-associated diseases. Since its approval, infliximab has revolutionised the treatment of Crohn’s disease and has shown benefit in a variety of other inflammatory conditions, but significant toxicities can occur that necessitate thorough screening protocols and periodic clinical evaluation.
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