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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Ingenol Mebutate


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Ingenol Mebutate volume of distribution

There is no volume of distribution quantity since ingenol mebutate is a topical treatment.

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What is Ingenol Mebutate

Ingenol mebutate was approved by the FDA in January 2012, and it is marketed under the name Picato Picato gel is indicated for the topical treatment of actinic keratosis. Before approval, ingenol mebutate was called PEP005 as an investigational drug. PEP005 is a selective small molecule activator of protein kinase C (PKC) extracted from the plant Euphorbia peplus, whose sap has been used as a traditional medicine for the treatment of skin conditions including warts and cancer. PEP005 also has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations.

Ingenol Mebutate mechanism of action

The exact mechanism of action of ingenol mebutate in actinic keratosis is unknown. It is presumed to involve primary necrosis then neutrophil-mediated inflammation and antibody-dependent cell death of residual disease cells. Additionally in early studies, PEP005 was shown to be an effective activator of PKC-delta and PKC-delta translocation into nucleus and membranes. PEP005 also downregulates the expression and activity of PKC-alpha. PEP005 induced modulation of PKCs leads to Ras/Raf/MAPK and p38 activation and AKT/PKB inhibition.

Dosage forms of Ingenol Mebutate

GelCutaneous use150 micrograms/g
GelCutaneous use500 micrograms/g
Geltopical0.015 %
Prescription Generics


International Brands



3-Ingenyl Angelate Ingenol 3-angelate


LEO Pharma Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Ingenol Mebutate

For the topical treatment of actinic keratosis.

Toxicity of Ingenol Mebutate

The most common adverse reactions are local skin reactions at the application site, headache, periorbital edema,and nasopharyngitis.

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