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2018 Price of Ingenol Mebutate
* price without discount in nearest pharmacy. Price may vary.
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Ingenol Mebutate volume of distribution
There is no volume of distribution quantity since ingenol mebutate is a topical treatment.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ingenol Mebutate
Ingenol mebutate was approved by the FDA in January 2012, and it is marketed under the name Picato Picato gel is indicated for the topical treatment of actinic keratosis. Before approval, ingenol mebutate was called PEP005 as an investigational drug. PEP005 is a selective small molecule activator of protein kinase C (PKC) extracted from the plant Euphorbia peplus, whose sap has been used as a traditional medicine for the treatment of skin conditions including warts and cancer. PEP005 also has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations.
Ingenol Mebutate mechanism of action
The exact mechanism of action of ingenol mebutate in actinic keratosis is unknown. It is presumed to involve primary necrosis then neutrophil-mediated inflammation and antibody-dependent cell death of residual disease cells. Additionally in early studies, PEP005 was shown to be an effective activator of PKC-delta and PKC-delta translocation into nucleus and membranes. PEP005 also downregulates the expression and activity of PKC-alpha. PEP005 induced modulation of PKCs leads to Ras/Raf/MAPK and p38 activation and AKT/PKB inhibition.
Dosage forms of Ingenol Mebutate
|Gel||Cutaneous use||150 micrograms/g|
|Gel||Cutaneous use||500 micrograms/g|
3-Ingenyl Angelate Ingenol 3-angelate
LEO Pharma Inc.
Humans and other mammals
Indication of Ingenol Mebutate
For the topical treatment of actinic keratosis.
Toxicity of Ingenol Mebutate
The most common adverse reactions are local skin reactions at the application site, headache, periorbital edema,and nasopharyngitis.
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