Save up -80% on Insulin Aspart

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Novolog

$561.921 carton (5 flexpens) 3 ml
price without discount in nearest pharmacy. Price may vary.

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Insulin Aspart volume of distribution

NovoLog has a low binding to plasma proteins, 0-9%, similar to regular human insulin. After subcutaneous administration in normal male volunteers (n=24), NovoLog was more rapidly eliminated than regular human insulin with an average apparent half-life of 81 minutes compared to 141 minutes for regular human insulin.

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What is Insulin Aspart

Insulin aspart is a recombinant, biosynthetic, fast-acting insulin analogue. It has a single amino acid substitution at position B28 where proline is replaced with aspartic acid. This substitution decreases its propensity to form hexamers and gives it a higher rate of absorption following subcutaneous administration compared to native insulin. Insulin aspart is produced in a genetically modified strain of _Saccharomyces cerevisiae_ and harvested from a bioreactor.

Insulin Aspart mechanism of action

Insulin aspart binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor autophosphorylates and phosphorylates numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. Activation of these proteins leads to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC), both of which play critical roles in metabolism and catabolism. In humans, insulin is stored in the form of hexamers; however, only insulin monomers are able to interact with IR. Substitution of the proline residue at B28 with aspartic acid reduces the tendency to form hexamers and results in a faster rate of absorption and onset of action and shorter duration of action.

Dosage forms of Insulin Aspart

FormRouteStrength
Injection, solutionintravenous; subcutaneous100[iU]/mL
Injection, suspensionsubcutaneous100[iU]/mL
Suspension for injectionSubcutaneous use100 U/ml

Prescription Generics

false

International Brands

Novolog

Synonyms

Aspart Aspart Insulin

Manufacturers

A S Medication Solutions

CAS number

116094-23-6

UNII

D933668QVX

State

liquid

Affected organisms

Humans and other mammals

Indication of Insulin Aspart

For the treatment of Type 1 or 2 diabetes mellitus. Should normally be used in conjunction with an intermediate or long-acting insulin.

Toxicity of Insulin Aspart

Inappropriately high dosages relative to food intake and/or energy expenditure may result in severe and sometimes prolonged and life-threatening hypoglycemia. Neurogenic (autonomic) signs and symptoms of hypoglycemia include trembling, palpitations, sweating, anxiety, hunger, nausea and tingling. Neuroglycopenic signs and symptoms of hypoglycemia include difficulty concentrating, lethargy/weakness, confusion, drowsiness, vision changes, difficulty speaking, headache, and dizziness. Mild hypoglycemia is characterized by the presence of autonomic symptoms. Moderate hypoglycemia is characterized by the presence of autonomic and neuroglycopenic symptoms. Individuals may become unconscious in severe cases of hypoglycemia.

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What is a NovoLog?

NovoLog is a fast-acting insulin that starts working about 15 minutes after the injection, reaches a peak after about 1 hour and continues to work for 2-4 hours. Insulin is a hormone that works by lowering the level of glucose (sugar) in the blood.

NovoLog is used to improve blood sugar control in adults and children with diabetes. This medicine is sometimes used with long-acting or intermediate-acting insulin. NovoLog is used to treat type 2 diabetes in adults. NovoLog is also used to treat type 1 diabetes in adults and children who are at least 2 years old.

NovoLog is a fast-acting insulin that starts working very quickly. After use, you must eat the food for 5-10 minutes.

Never use a pen or cartridge with another person. Sharing injection pens or cartridges can allow diseases, such as hepatitis or HIV, to move from one person to another. You should not use NovoLog if you have an episode of hypoglycemia (low blood sugar).