Save up -80% on Insulin Degludec

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Tresiba

$612.411 carton (three 3ml flextouch pens) 200 units/ml
price without discount in nearest pharmacy. Price may vary.

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Insulin Degludec volume of distribution

Insulin degludec concentration reach steady state levels after 3-4 days. The affinity of insulin degludec to serum albumin corresponds to a plasma protein binding of >99% in human plasma. The half-life after subcutaneous administration is determined primarily by the rate of absorption from the subcutaneous tissue.

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What is Insulin Degludec

Insulin Degludec is an ultra-long-acting insulin analogue used for glycemic control in Diabetes Mellitus. Insulin and its analogues lower blood glucose levels by stimulating peripheral glucose uptake and by preventing hepatic glucose production. Compared to endogenous insulin, this product has an added hexadecanedioic acid to lysine at the B29 position which allows for the formation of multi-hexamers. When injected subcutaneously, these multi-hexamers form a drug depot store from which monomers are slowly and continuously absorbed into the circulation. As a result, Insulin Degludec has a protracted time action profile due to the delayed absorption from subcutaneous tissue depots into the systemic circulation. Compared to available long-acting analogues such as insulin glargine and insulin detemir, which have a duration of action of 20-24 hours, insulin degludec provides a consistent level of basal insulin over 42 hours with a low peak:trough ratio. Limitations of shorter acting analogues include more frequent dosing and less stable pharmacokinetics, which may negatively impact patient adherence and glucose control, particularly nocturnal control. Insulin Degludec was approved by the FDA in September 2015 as the product Tresiba, for use in providing glycemic control to adults with diabetes mellitus.

Insulin Degludec mechanism of action

Insulin and its analogues lower blood glucose levels by stimulating peripheral glucose uptake and by preventing hepatic glucose production. Compared to endogenous insulin, Insulin Degludec has an added hexadecanedioic acid to lysine at the B29 position which allows for the formation of multi-hexamers in subcutaneous tissues. When injected subcutaneously, these multi-hexamers form a drug depot store that slowly release. As a result, Insulin Degludec has a protracted time action profile due to the delayed absorption from subcutaneous tissue depots into the systemic circulation

Dosage forms of Insulin Degludec

DrugDosageQuantityPrice
Tresiba100 units/ml1 carton (five 3ml flextouch pens)$535
Tresiba200 units/ml1 carton (five 3ml flextouch pens)$614

Prescription Generics

false

International Brands

Tresiba

Synonyms

Manufacturers

Novo Nordisk

CAS number

844439-96-9

UNII

54Q18076QB

State

Affected organisms

Indication of Insulin Degludec

Insulin degludec is indicated to improve glycemic control in adults with diabetes mellitus.

Toxicity of Insulin Degludec

Observe for signs and symptoms of hypoglycemia, hypokalemia, and fluid retention and heart failure with concomitant use of Thiazolidinediones. Pregnancy Category C

RX24 Drugs Disclaimer: before buying a Insulin Degludec on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Tresiba?

Tresiba is a long-acting insulin that starts working several hours after the injection and works evenly for 24 hours. Insulin is a hormone that works by lowering the level of glucose (sugar) in the blood.

Tresiba is used to improve blood sugar control in patients aged 1 and older with diabetes. Tresiba can be used for type 1 or type 2 diabetes. You should not use Tresiba if you have an episode of hypoglycemia (low blood sugar).

Never share a Tresiba FlexTouch pen with another person. Sharing injecting pens may allow diseases, such as hepatitis or HIV, to move from one person to another.