Save up -80% on Insulin Detemir
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Levemir
|$446.08||1 carton (5 flextouch pens)/3 ml|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Insulin Detemir coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Insulin Detemir every time. What are you waiting for? Claim your prescription drug card now!
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Insulin Detemir volume of distribution
The volume of distribution is approximately 0.1 L/kg and the bioavailability is 60%.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Insulin Detemir
Insulin detemir is a long-acting human insulin analogue used to maintain basal levels of insulin in diabetic individuals. It is produced using recombinant DNA technology in yeast cells. This insulin analogue has a 14-C fatty acid, myristic acid, bound to the lysine amino acid at position B29. The myristoyl side chain increases self-association and albumin binding. This along with slow systemic absorption from the injection site prolongs distribution of the hormone into tissues and results in a long duration of action. Novo Nordisk markets insulin detemir under the trade name Levemir.
Insulin Detemir mechanism of action
Insulin detemir binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor autophosphorylates and phosphorylates numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. Activation of these proteins leads to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC), both of which play critical roles in metabolism and catabolism. Insulin detemir long duration of action appears to be a result of slow systemic absorption from the injection site and delayed distribution to target tissues. The myristic acid side chain on insulin detemir increases self-association and gives it a high binding affinity to serum albumin. These features slows its distribution into target tissues and prolongs its duration of action.
Dosage forms of Insulin Detemir
|Implant||soft tissue||14.2 mg/mL|
|Injection, solution||subcutaneous||14.2 mg/mL|
Insulin detemir Insulin detemir recombinant
Physicians Total Care, Inc.
Humans and other mammals
Indication of Insulin Detemir
For the treatment of type 1 or 2 diabetes mellitus. May be used in combination with oral anti-diabetic agents in type 2 diabetic patients who are not in adequate metabolic control with oral anti-diabetic agents alone.
Toxicity of Insulin Detemir
Hypoglycemia may occur with inappropriately high doses. Neurogenic (autonomic) signs and symptoms of hypoglycemia include trembling, palpitations, sweating, anxiety, hunger, nausea and tingling. Neuroglycopenic signs and symptoms of hypoglycemia include difficulty concentrating, lethargy/weakness, confusion, drowsiness, vision changes, difficulty speaking, headache, and dizziness. Mild hypoglycemia is characterized by the presence of autonomic symptoms. Moderate hypoglycemia is characterized by the presence of autonomic and neuroglycopenic symptoms. Individuals may become unconscious in severe cases of hypoglycemia. Injection site reactions may also occur. Symptoms include: redness, inflammation, bruising, swelling and itching at the injection site.
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What is Levemir?
Levemir is a hypoglycemic drug that is identical in its chemical structure and action to human insulin. This drug belongs to the group of human recombinant long-acting insulin.
Special attention is paid to the control of gestational diabetes. Levemir is the drug of choice for pregnant women who have high blood sugar. Serious studies have proven its safety and efficacy for pregnant women, as well as for children from 2 years.
Keep in mind that spoiled insulin remains as transparent as fresh. The quality of the drug can not be determined by its appearance. Therefore, do not buy Levemir from the hands, according to private announcements. Get it in large reputable pharmacies whose employees know the rules of storage and are not lazy to follow them.