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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Insulin Glargine

Lantus 100 unit/ml cartridge

$14.35

ml

* price without discount in nearest pharmacy. Price may vary.

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Insulin Glargine volume of distribution

NameDosageStrengthRouteLabeller
AbasaglarInjection, solution100 Units/mlSubcutaneousEli Lilly Nederland B.V.

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What is Insulin Glargine

Insulin glargine is produced by recombinant DNA technology using a non-pathogenic laboratory strain of Escherichia coli (K12) as the production organism. It is an analogue of human insulin made by replacing the asparagine residue at position A21 of the A-chain with glycine and adding two arginines to the C-terminus (positions B31 and 32) of the B-chain. The resulting protein is soluble at pH 4 and forms microprecipitates at physiological pH 7.4. Small amounts of insulin glargine are slowly released from microprecipitates giving the drug a long duration of action (up to 24 hours) and no pronounced peak concentration.

Insulin Glargine mechanism of action

Insulin glargine binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor autophosphorylates and phosphorylates numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. Activation of these proteins leads to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC), both of which play critical roles in metabolism. Insulin glargine is completely soluble at pH 4, the pH of administered solution, and has low solubility at physiological pH 7.4. Upon subcuteous injection, the solution is neutralized resulting in the formation of microprecipitates. Small amounts of insulin glargine are released from microprecipitates giving the drug a relatively constant concentration over time profile over 24 hours with no pronounced peak. This release mechanism allows the drug to mimic basal insulin levels within the body.

Dosage forms of Insulin Glargine

DrugPriceDosage
Lantus SoloStar 100 unit/ml Solution 1 Box = Five 3ml Syringes$223.89box
Lantus 100 unit/ml Solution 10ml Vial$111.88vial
Lantus for OptiClik 100 unit/ml Solution 3ml Cartridge$44.78cartridge
Lantus 100 unit/ml cartridge$14.35ml
Lantus solostar 100 unit/ml$14.35ml
Prescription Generics

false

International Brands

Basaglar, Lantus, Lantus SoloStar, Toujeo

Synonyms

Insulin Glargine (rDNA origin) Insulin glargine recombinant

Manufacturers

Eli Lilly Canada Inc

CAS number

160337-95-1

UNII

2ZM8CX04RZ

State

liquid

Affected organisms

Humans and other mammals

Indication of Insulin Glargine

For the treatment of Type 1 or 2 diabetes mellitus in patients over 17 years old who require a long-acting (basal) insulin for the control of hyperglycemia. May be used in pediatric patients with Type 1 diabetes mellitus who require a long-acting (basal) insulin for glycemic control.

Toxicity of Insulin Glargine

Inappropriately high dosages relative to food intake and/or energy expenditure may result in severe and sometimes prolonged and life-threatening hypoglycemia. Neurogenic (autonomic) signs and symptoms of hypoglycemia include trembling, palpitations, sweating, anxiety, hunger, nausea and tingling. Neuroglycopenic signs and symptoms of hypoglycemia include difficulty concentrating, lethargy/weakness, confusion, drowsiness, vision changes, difficulty speaking, headache, and dizziness. Mild hypoglycemia is characterized by the presence of autonomic symptoms. Moderate hypoglycemia is characterized by the presence of autonomic and neuroglycopenic symptoms. Individuals may become unconscious in severe cases of hypoglycemia. Other adverse events that may occur include allergic reaction, injection site reaction, lipodystrophy, pruritis, and rash.

RX24 Drugs Disclaimer: before buying a Insulin Glargine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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