Save up -80% on Insulin Human
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Novolin N
|$26.79||1 vial (10ml) 100 units/ml|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Novolin N coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Insulin Human every time. What are you waiting for? Claim your prescription drug card now!
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Insulin Human volume of distribution
0.15 L/kg. When injected subcutaneously, the glucose- lowering effect of Novolin N begins approximately 1 to 2 hours post-dose.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Insulin Human
Insulin human is a 51 residue peptide hormone, composed of two amino acid chains covalently linked by disulfide bonds. The structure is identical to native human insulin. Recombinant insulin is synthesized by recombinant DNA techncology. Inserting the human insulin gene into the Escherichia coli bacteria or Saccharomyces cerevisiae produces insulin for human use. Inhalable insulin is a powdered form of insulin regular, delivered with a nebulizer into the lungs where it is absorbed. Exubera, developed by Inhale Therapeutics (later named Nektar Therapeutics), became the first inhaled insulin product to be marketed in 2006 by Pfizer, but poor sales led Pfizer to withdraw it in 2007. Afrezza, a monomeric inhaled insulin developed by Mannkind, was approved by the FDA in 2014.
Insulin Human mechanism of action
The primary activity of insulin is the regulation of glucose metabolism. Insulin promotes glucose and amino acid uptake into muscle and adipose tissues, and other tissues except brain and liver. It also has an anabolic role in stimulating glycogen, fatty acid, and protein synthesis. Insulin inhibits gluconeogenesis in the liver. Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism and catabolism.
Dosage forms of Insulin Human
|Suspension for injection||Subcutaneous use||100 iu/ml|
|Suspension for injection||Subcutaneous use||40 iu/ml|
|Solution for injection||Subcutaneous or intravenous use||100 iu/ml|
human insulin (rDNA) Inhaled insulin
Sanofi Aventis U.S. Llc
Humans and other mammals
Indication of Insulin Human
Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.
Toxicity of Insulin Human
Hypoglycemia is one of the most frequent adverse events experienced by insulin users.
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