Save up -80% on Interferon Alfa-2a, Recombinant
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2018 Price of Interferon Alfa-2a, Recombinant
* price without discount in nearest pharmacy. Price may vary.
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Interferon Alfa-2a, Recombinant volume of distribution
* 0.223 to 0.748 L/kg healthy people
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Interferon Alfa-2a, Recombinant
Interferon a (human leukocyte protein moiety reduced). A type I interferon consisting of 165 amino acid residues with lysine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent. An oral form is being developed by Amarillo Biosciences.
Interferon Alfa-2a, Recombinant mechanism of action
Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
Dosage forms of Interferon Alfa-2a, Recombinant
|Liquid||intramuscular; subcutaneous||6000000 unit|
|Powder for solution||intramuscular; subcutaneous||18000000 unit|
|Powder for solution||intramuscular; subcutaneous||3000000 unit|
Roferon A Soln Inj 6 Million
Interferon alfa-2a Interferon alfa-2a (recombinant)
Hoffmann La Roche Limited
Humans and other mammals
Indication of Interferon Alfa-2a, Recombinant
For the treatment of chronic hepatitis C, hairy cell leukemia, AIDS-related Kaposi’s sarcoma, and chronic myelogenous leukemia. Also for the treatment of oral warts arising from HIV infection.
Toxicity of Interferon Alfa-2a, Recombinant
Interferon alfa-2 may cause serious adverse effects such as anemia; autoimmune diseases, including vasculitis, arthritis, hemolytic anemia, and erythematosus syndrome; cardiotoxicity; hepatotoxicity; hyperthyroidism or hypothyroidism; transient ischemic attacks; leukopenia; neurotoxicity; peripheral neuropathy; and thrombocytopenia. Some lesser side effects that may not need medical attention include blurred vision, change in taste or metallic taste, cold sores or stomatitis, diarrhea, dizziness, dry mouth, dry skin or itching, flu-like syndrome, increased sweating, leg cramps, loss of appetite, nausea or vomiting, skin rash, unusual tiredness, weight loss, and partial loss of hair.
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