Save up -80% on Interferon Alfa-2B

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Intron A

$312.631 vial/10 million IU
price without discount in nearest pharmacy. Price may vary.

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Interferon Alfa-2B volume of distribution

Interferon-alpha is well absorbed after subcutaneous or intramuscular administration, with a bioavailability greater than 80%. The bioavailability of peginterferon alpha-2a is 61%. Interferon-alpha volume of distribution has been reported to range from 12-40L, with a mean of 31L or 0.4L/kg in healthy volunteers.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Interferon Alfa-2B

Interferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent.

Interferon Alfa-2B mechanism of action

Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which upon dimerization activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.

Dosage forms of Interferon Alfa-2B

FormRouteStrength
Injection, solutionintralesional; intramuscular; subcutaneous19.2 ug/.5mL
Injection, solutionintramuscular; subcutaneous11.6 ug/.5mL
Kit

Prescription Generics

false

International Brands

Intron A

Synonyms

Interferon alfa-2b Interferon .-2b

Manufacturers

Merck Canada Inc

CAS number

98530-12-2

UNII

43K1W2T1M6

State

liquid

Affected organisms

Humans and other mammals

Indication of Interferon Alfa-2B

For the treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi’s sarcoma.

Toxicity of Interferon Alfa-2B

There is limited experience with overdosage. Postmarketing surveillance includes reports of patients receiving a single dose as great as 10 times the recommended dose. In general, the primary effects of an overdose are consistent with the effects seen with therapeutic doses of interferon alfa-2b. Hepatic enzyme abnormalities, renal failure, hemorrhage, and myocardial infarction have been reported with single administration overdoses and/or with longer durations of treatment than prescribed. Toxic effects after ingestion of interferon alfa-2b are not expected because interferons are poorly absorbed orally.

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