Save up -80% on Interferon Alfa-2b, Recombinant
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2018 Price of Interferon Alfa-2b, Recombinant
Intron a 3 million unit/ml pen
* price without discount in nearest pharmacy. Price may vary.
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Interferon Alfa-2b, Recombinant volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Interferon Alfa-2b, Recombinant
Interferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent.
Interferon Alfa-2b, Recombinant mechanism of action
Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which upon dimerization activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
Dosage forms of Interferon Alfa-2b, Recombinant
|Injection, solution||intralesional; intramuscular; subcutaneous||19.2 ug/.5mL|
|Injection, solution||intramuscular; subcutaneous||11.6 ug/.5mL|
Interferon alfa-2b Interferon .-2b
Merck Canada Inc
Humans and other mammals
Indication of Interferon Alfa-2b, Recombinant
For the treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi’s sarcoma.
Toxicity of Interferon Alfa-2b, Recombinant
There is limited experience with overdosage. Postmarketing surveillance includes reports of patients receiving a single dose as great as 10 times the recommended dose. In general, the primary effects of an overdose are consistent with the effects seen with therapeutic doses of interferon alfa-2b. Hepatic enzyme abnormalities, renal failure, hemorrhage, and myocardial infarction have been reported with single administration overdoses and/or with longer durations of treatment than prescribed. Toxic effects after ingestion of interferon alfa-2b are not expected because interferons are poorly absorbed orally.
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