Save up -80% on Interferon beta-1a

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
Pharmacists and Patients support.

2019 Price of Rebif

$7,539.971 carton (12 syringes) 22mcg
price without discount in nearest pharmacy. Price may vary.

Claim your free Interferon beta-1a discount card

We offer free Rebif coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Interferon beta-1a every time. What are you waiting for? Claim your prescription drug card now!

Walgreens pharmacy
Walgreens pharmacy
CVS pharmacy
CVS pharmacy
Walmart pharmacy
Walmart pharmacy
Ride AID pharmacy
Ride AID pharmacy
CVS Target pharmacy
CVS Target pharmacy
Kroger pharmacy
Kroger pharmacy
rx

Get your Prescription

safe

It’s safe and free

pharmacy

Buy drugs in pharmacy

save money

Save money each time

Interferon beta-1a volume of distribution

Systemic clearance values in monkeys, rats, and mice decreased, respectively, from 232, 261, and 247 ml/h/kg for the unmodified IFN-beta-1a to 30.5, 19.2, and 18.7 ml/h/kg for the PEGylated form, while volume of distribution values decreased from 427, 280, and 328 ml/kg to 284, 173, and 150 ml/kg. The decreased clearance and volume of distribution resulted in higher serum antiviral activity in the PEG IFN-beta-1a-treated animals. In the rat, a more extensive set of dosing routes was investigated, including intraperitoneal, intratracheal, and oral administration.

RX Prescription
Ask Your therapeut before taking any drugs.

About RX24Drugs

2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Interferon beta-1a

Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta.

Interferon beta-1a mechanism of action

Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha.

Dosage forms of Interferon beta-1a

FormRouteStrength
Injection, powder, lyophilized, for solutionintramuscular30 ug/mL
Injection, solutionintramuscular30 ug/.5mL

Prescription Generics

false

International Brands

Avonex

Synonyms

Fibroblast interferon IFN-beta

Manufacturers

Biogen Canada Inc

CAS number

145258-61-3

UNII

XRO4566Q4R

State

liquid

Affected organisms

Indication of Interferon beta-1a

For treatment of relapsing/remitting multiple sclerosis, also for condyloma acuminatum

Toxicity of Interferon beta-1a

The manufacturer of interferon beta-1a (Rebif) states that, although patients receiving interferon beta-1a may receive concomitant vaccination, the overall effectiveness of vaccination in patients receiving interferon beta has not been determined. In a nonrandomized study in patients with multiple sclerosis, those receiving interferon beta-1a (Rebif; 12 million units (44 ug) 3 times weekly) for at least 6 months were vaccinated with influenza virus vaccine inactivated and the seroconversion rate was compared to that in patients not receiving the drug.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Interferon beta-1a on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

Get lower price on Interferon beta-1a now!