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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Interferon beta-1a

Rebif 22 mcg/0.5 ml syringe

$247.79

syringe

* price without discount in nearest pharmacy. Price may vary.

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Interferon beta-1a volume of distribution

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What is Interferon beta-1a

Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta.

Interferon beta-1a mechanism of action

Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha.

Dosage forms of Interferon beta-1a

FormRouteStrength
Injection, powder, lyophilized, for solutionintramuscular30 ug/mL
Injection, solutionintramuscular30 ug/.5mL
Prescription Generics

false

International Brands

Avonex

Synonyms

Fibroblast interferon IFN-beta

Manufacturers

Biogen Canada Inc

CAS number

145258-61-3

UNII

XRO4566Q4R

State

liquid

Affected organisms

Indication of Interferon beta-1a

For treatment of relapsing/remitting multiple sclerosis, also for condyloma acuminatum

Toxicity of Interferon beta-1a

RX24 Drugs Disclaimer: before buying a Interferon beta-1a on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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