Save up -80% on Interferon beta-1a
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Price of Interferon beta-1a
Rebif 22 mcg/0.5 ml syringe
* price without discount in nearest pharmacy. Price may vary.
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Interferon beta-1a volume of distribution
What is Interferon beta-1a
Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta.
Interferon beta-1a mechanism of action
Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha.
Dosage forms of Interferon beta-1a
|Injection, powder, lyophilized, for solution||intramuscular||30 ug/mL|
|Injection, solution||intramuscular||30 ug/.5mL|
Biogen Canada Inc
Indication of Interferon beta-1a
For treatment of relapsing/remitting multiple sclerosis, also for condyloma acuminatum
Toxicity of Interferon beta-1a
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