Save up -80% on Interferon beta-1b
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Extavia
|$449.45||1 kit (1 blister pack) 0.3mg|
|price without discount in nearest pharmacy. Price may vary.|
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Interferon beta-1b volume of distribution
Steady-state volume of distribution values ranged from 0.25 L/kg to 2.88 L/kg. Three-times-a-week intravenous dosing for two weeks resulted in no accumulation of interferon beta-1b in sera of patients. Pharmacokinetic parameters after single and multiple intravenous doses of Interferon beta-1b were comparable.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Interferon beta-1b
Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
Interferon beta-1b mechanism of action
Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha.
Dosage forms of Interferon beta-1b
|Powder and solvent for solution for injection||Subcutaneous use||0.25 mg/ml|
Fibroblast interferon IFN-beta
Bayer Health Care Pharmaceuticals Inc.
Humans and other mammals
Indication of Interferon beta-1b
Interferon beta-1b is a drug used for the treatment of relapsing/remitting multiple sclerosis. It has been shown to slow the advance of the disease as well as to decrease the frequency of attacks.
Toxicity of Interferon beta-1b
Administration of Interferon beta-1b (doses of up to 0.33 mg/kg/day) to normally cycling female rhesus monkeys had no apparent adverse effects on either menstrual cycle duration or associated hormonal profiles (progesterone and estradiol) when administered over three consecutive menstrual cycles. The highest dose tested is approximately 30 times the recommended human dose of 0.25 mg on a body surface area (mg/sq m) basis. The potential for other effects on fertility or reproductive performance was not evaluated.
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