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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Extavia

$449.451 kit (1 blister pack) 0.3mg
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Interferon beta-1b volume of distribution

Steady-state volume of distribution values ranged from 0.25 L/kg to 2.88 L/kg. Three-times-a-week intravenous dosing for two weeks resulted in no accumulation of interferon beta-1b in sera of patients. Pharmacokinetic parameters after single and multiple intravenous doses of Interferon beta-1b were comparable.

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What is Interferon beta-1b

Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD

Interferon beta-1b mechanism of action

Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha.

Dosage forms of Interferon beta-1b

FormRouteStrength
Powder and solvent for solution for injectionSubcutaneous use0.25 mg/ml

Prescription Generics

false

International Brands

Betaseron

Synonyms

Fibroblast interferon IFN-beta

Manufacturers

Bayer Health Care Pharmaceuticals Inc.

CAS number

145155-23-3

UNII

TTD90R31WZ

State

liquid

Affected organisms

Humans and other mammals

Indication of Interferon beta-1b

Interferon beta-1b is a drug used for the treatment of relapsing/remitting multiple sclerosis. It has been shown to slow the advance of the disease as well as to decrease the frequency of attacks.

Toxicity of Interferon beta-1b

Administration of Interferon beta-1b (doses of up to 0.33 mg/kg/day) to normally cycling female rhesus monkeys had no apparent adverse effects on either menstrual cycle duration or associated hormonal profiles (progesterone and estradiol) when administered over three consecutive menstrual cycles. The highest dose tested is approximately 30 times the recommended human dose of 0.25 mg on a body surface area (mg/sq m) basis. The potential for other effects on fertility or reproductive performance was not evaluated.

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