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Price of Interferon beta-1b
Extavia 0.3 mg kit
* price without discount in nearest pharmacy. Price may vary.
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Interferon beta-1b volume of distribution
* 0.25 to 2,88 L/kg
What is Interferon beta-1b
Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
Interferon beta-1b mechanism of action
Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha.
Dosage forms of Interferon beta-1b
|Powder and solvent for solution for injection||Subcutaneous use||0.25 mg/ml|
Bayer Health Care Pharmaceuticals Inc.
Humans and other mammals
Indication of Interferon beta-1b
Interferon beta-1b is a drug used for the treatment of relapsing/remitting multiple sclerosis. It has been shown to slow the advance of the disease as well as to decrease the frequency of attacks.
Toxicity of Interferon beta-1b
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