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Price of Interferon gamma-1b
Actimmune 2 million unit vial
* price without discount in nearest pharmacy. Price may vary.
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Interferon gamma-1b volume of distribution
What is Interferon gamma-1b
Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography.
The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.
Interferon gamma-1b mechanism of action
Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.
Dosage forms of Interferon gamma-1b
|Injection, solution||subcutaneous||100 ug/.5mL|
Interferon gamma-1b, recombinant
Hznp Usa, Inc.
Indication of Interferon gamma-1b
Interferon gamma-1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis.
Toxicity of Interferon gamma-1b
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