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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Interferon gamma-1b

Actimmune 2 million unit vial



* price without discount in nearest pharmacy. Price may vary.

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Interferon gamma-1b volume of distribution

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What is Interferon gamma-1b

Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.

Interferon gamma-1b mechanism of action

Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.

Dosage forms of Interferon gamma-1b

Injection, solutionsubcutaneous100 ug/.5mL
Prescription Generics


International Brands



IFN-gamma-1b Interferon gamma-1b, recombinant


Hznp Usa, Inc.

CAS number






Affected organisms

Indication of Interferon gamma-1b

Interferon gamma-1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis.

Toxicity of Interferon gamma-1b

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