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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Actimmune

$4,317.251 vial (0.5ml) 100mcg
price without discount in nearest pharmacy. Price may vary.

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Interferon gamma-1b volume of distribution

Following subcutaneous injection of a single interferon gamma-1b dose of 100 ug/sq m in healthy men, more than 89% of the dose is slowly absorbed and peak plasma concentrations (0.6 ng/mL) are attained 7 hours after the dose. There was no evidence of accumulation in healthy men following subcutaneous administration of 100 ug/sq m once daily for 12 days.

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What is Interferon gamma-1b

Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.

Interferon gamma-1b mechanism of action

Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.

Dosage forms of Interferon gamma-1b

FormRouteStrength
Injection, solutionsubcutaneous100 ug/.5mL

Prescription Generics

false

International Brands

Actimmune

Synonyms

IFN-gamma-1b Interferon gamma-1b, recombinant

Manufacturers

Hznp Usa, Inc.

CAS number

98059-61-1

UNII

21K6M2I7AG

State

liquid

Affected organisms

Indication of Interferon gamma-1b

Interferon gamma-1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis.

Toxicity of Interferon gamma-1b

Central nervous system adverse reactions including decreased mental status, gait disturbance and dizziness have been observed, particularly in cancer patients receiving doses greater than 100 ug/m2/day by intravenous or intramuscular administration. These abnormalities were reversible within a few days upon dose reduction or discontinuation of therapy. Reversible neutropenia, elevation of hepatic enzymes and of triglycerides, and thrombocytopenia have also been observed.

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