Save up -80% on Ipratropium bromide
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Price of Ipratropium bromide
Atrovent 0.03 % Spray
* price without discount in nearest pharmacy. Price may vary.
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Ipratropium bromide volume of distribution
* 4.6 L/kg
What is Ipratropium bromide
A muscarinic antagonist structurally related to atropine but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic. (PubChem)
Ipratropium bromide mechanism of action
Ipratropium bromide is an anticholinergic agent. It blocks muscarinic cholinergic receptors, without specificity for subtypes, resulting in a decrease in the formation of cyclic guanosine monophosphate (cGMP). Most likely due to actions of cGMP on intracellular calcium, this results in decreased contractility of smooth muscle.
Dosage forms of Ipratropium bromide
|Spray, metered||nasal||21 ug/1|
|Spray, metered||nasal||42 ug/1|
Apo-ipravent Solution – Inh 250mcg/ml
3-hydroxy-8-isopropyl-1H,5H-tropanium bromide ()-tropate
Humans and other mammals
Indication of Ipratropium bromide
For maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.
Toxicity of Ipratropium bromide
LD sub 50 /sub =1001mg/kg (orally in mice)
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