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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Irbesartan

Avapro 75 mg tablet

$2.21

tablet

* price without discount in nearest pharmacy. Price may vary.

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Irbesartan volume of distribution

* 53 to 93 L

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What is Irbesartan

Irbesartan is an angiotensin receptor blocker (ARB) used mainly for the treatment of hypertension. It competes with angiotensin II for binding at the AT1 receptor subtype. Unlike ACE inhibitors, ARBs do not have the adverse effect of dry cough. The use of ARBs is pending revision due to findings from several clinical trials suggesting that this class of drugs may be associated with a small increased risk of cancer.

Irbesartan mechanism of action

Irbesartan is a nonpeptide tetrazole derivative and an angiotensin II antagonist that selectively blocks the binding of angiotensin II to the AT sub 1 /sub receptor. In the renin-angiotensin system, angiotensin I is converted by angiotensin-converting enzyme (ACE) to form angiotensin II. Angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle. Irbesartan, by blocking the binding of angiotensin II to the AT sub 1 /sub receptor, promotes vasodilation and decreases the effects of aldosterone. The negative feedback regulation of angiotensin II on renin secretion is also inhibited, but the resulting rise in plasma renin concentrations and consequent rise in angiotensin II plasma concentrations do not counteract the blood pressurendash;lowering effect that occurs. The action of ARBs is different from ACE inhibitors, which block the conversion of angiotensin I to angiotensin II, meaning that the production of angiotensin II is not completely inhibited, as the hormone can be formed via other enzymes. Also, unlike ACE inhibitors, irbesartan and other ARBs do not interfere with response to bradykinins and substance P, which allows for the absence of adverse effects that are present in ACE inhibitors (eg. dry cough).

Dosage forms of Irbesartan

DrugDosageQuantityPrice
Avapro75mg84 Tablet$97.00
Avapro150mg84 Tablet$137.00
Avapro300mg28 Tablet$49.00
Irbesartan75mg100 Tablet$59.00
Irbesartan150mg100 Tablet$78.00
Irbesartan300mg100 Tablet$58.02
Irbesartan/Hctz300/25mg100 Tablet$68.40
Irbesartan/Hctz150/12.5mg100 Tablet$60.40
Irbesartan/Hctz300/12.5mg100 Tablet$66.40
Avalide300/25mg84 Tablet$110.00
Avalide150/12.5mg84 Tablet$92.00
Avalide300/12.5mg56 Tablet$74.00
Prescription Generics

false

International Brands

Act Irbesartan

Synonyms

2-Butyl-3-{(2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl}-1,3-diazaspiro(4.4)non-1-en-4-one Avapro

Manufacturers

Actavis Pharma Company

CAS number

138402-11-6

UNII

J0E2756Z7N

State

solid

Affected organisms

Humans and other mammals

Indication of Irbesartan

For the treatment of hypertension, as well as diabetic nephropathy with an elevated serum creatinine and proteinuria (gt;300 mg/day) in patients with type 2 diabetes and hypertension. Irbesartan is also used as a second line agent in the treatment of congestive heart failure.

Toxicity of Irbesartan

Hypotension and tachycardia; bradycardia might also occur from overdose, LD sub 50 /sub =mg/kg(orally in rat)

RX24 Drugs Disclaimer: before buying a Irbesartan on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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