Save up -80% on Isocarboxazid
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2018 Price of Isocarboxazid
Marplan 10 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Isocarboxazid volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Isocarboxazid
An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311)
Isocarboxazid mechanism of action
Isocarboxazid works by irreversibly blocking the action of a chemical substance known as monoamine oxidase (MAO) in the nervous system. MAO subtypes A and B are involved in the metabolism of serotonin and catecholamine neurotransmitters such as epinephrine, norepinephrine, and dopamine. Isocarboxazid, as a nonselective MAO inhibitor, binds irreversibly to monoamine oxidasendash;A (MAO-A) and monoamine oxidasendash;B (MAO-B). The reduced MAO activity results in an increased concentration of these neurotransmitters in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. This increased availability of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors.
Dosage forms of Isocarboxazid
Validus Pharmaceuticals LLC
Humans and other mammals
Indication of Isocarboxazid
May be used to treat major depressive disorder.
Toxicity of Isocarboxazid
Signs of overdose include severe anxiety, confusion, convulsions, cool clammy skin, severe dizziness, severe drowsiness, fast and irregular pulse, fever, hallucinations, severe headache, high or low blood pressure, hyperactive reflexes, muscle stiffness, respiratory depression or failure, slowed reflexes, sweating, severe trouble in sleeping, and unusual irritability.
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