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2018 Price of Isoniazid
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Isoniazid volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Isoniazid
Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Isoniazid mechanism of action
Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular i Mycobacterium tuberculosis /i organisms. Specifically isoniazid inhibits InhA, the enoyl reductase from i Mycobacterium tuberculosis /i , by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.
Dosage forms of Isoniazid
|Injection, solution||intramuscular||100 mg/mL|
Dom-isoniazid 300mg Tablets
Indication of Isoniazid
For the treatment of all forms of tuberculosis in which organisms are susceptible.
Toxicity of Isoniazid
LD sub 50 /sub 100 mg/kg (Human, oral). Adverse reactions include rash, abnormal liver function tests, hepatitis, peripheral neuropathy, mild central nervous system (CNS) effects. In vivo, Isoniazid reacts with pyridoxal to form a hydrazone, and thus inhibits generation of pyridoxal phosphate. Isoniazid also combines with pyridoxal phosphate; high doses interfere with the coenzyme function of the latter.
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