Save up -80% on Isoniazid
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Stanozide
|price without discount in nearest pharmacy. Price may vary.|
We offer free Isoniazid coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Isoniazid every time. What are you waiting for? Claim your prescription drug card now!
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Isoniazid volume of distribution
Isoniazid readily diffuses to all body fluids and tissues, with the largest accumulation occurring in the liver. Volume of distribution (Vd): 0.6 l/kg.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Isoniazid
Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Isoniazid mechanism of action
Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular i Mycobacterium tuberculosis /i organisms. Specifically isoniazid inhibits InhA, the enoyl reductase from i Mycobacterium tuberculosis /i , by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.
Dosage forms of Isoniazid
|Injection, solution||intramuscular||100 mg/mL|
Dom-isoniazid 300mg Tablets
Indication of Isoniazid
For the treatment of all forms of tuberculosis in which organisms are susceptible.
Toxicity of Isoniazid
LD sub 50 /sub 100 mg/kg (Human, oral). Adverse reactions include rash, abnormal liver function tests, hepatitis, peripheral neuropathy, mild central nervous system (CNS) effects. In vivo, Isoniazid reacts with pyridoxal to form a hydrazone, and thus inhibits generation of pyridoxal phosphate. Isoniazid also combines with pyridoxal phosphate; high doses interfere with the coenzyme function of the latter.
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