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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Vasodilan

$32.7090 tablets/10 mg
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Isoxsuprine volume of distribution

Isoxsuprine (0.6 mg/kg) administered IV to 6 standing horses produced substantial, transient decreases in systemic blood pressure, systemic vascular resistance, and stroke volume. It also produced substantial, transient increases in heart rate, cardiac output, and purposeful movement. Plasma concentrations of isoxsuprine peaked soon after the drug was administered IV and then decreased over a 12-hour period in a biexponential manner, with distribution and elimination half-lives of 14 minutes and 2.67 hours, respectively. Total body clearance and steady-state volume of distribution were calculated to be 53.8 ml/min/kg and 10.5 L/kg, respectively. When a recommended therapeutic dosage regimen (0.6 mg/kg 2 times a day, per os) was used in 4 of these horses, changes were not detected. Isoxsuprine was not detected in plasma after the drug was given orally. We conclude that 0.6 mg of isoxsuprine/kg given orally every 12 hours is not likely to produce cardiovascular changes in the resting horse and that this is probably because plasma concentrations are not high enough to do so.

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What is Isoxsuprine

A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.

Isoxsuprine mechanism of action

Isoxsuprine hydrochloride is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.

Dosage forms of Isoxsuprine

DrugDosageQuantityPrice
Isoxsuprine10mg100 Tablet$79.42
Vasodilan10mg90 capsules$42.90
Vasodilan20mg30 tablets$34.54

Prescription Generics

false

International Brands

Isoxsuprine Hydrochloride

Synonyms

Manufacturers

Bi Coastal Pharma International Limited Liability Company

CAS number

395-28-8

UNII

R15UI3245N

State

solid

Affected organisms

Indication of Isoxsuprine

Isoxsuprine it is used in humans for treatment of premature labor, i.e. a tocolytic, and as a vasodilator for the treatment of cerebral vascular insufficiency, Raynaud’s phenomenon, and other conditions. Isoxsuprine may increase the heart rate, cause changes in blood pressure, and irritate the GI tract.

Toxicity of Isoxsuprine

The acute toxicity of isoxsuprine was examined in mice, rats, and dogs. Oral doses lethal to half the animals were greater than 1000 mg/kg. Intravenous and intraperitoneal toxicities were from five to twenty times greater. Prolonged oral administration of 100–600 mg/kg and 100–400 mg/kg to rats and dogs, respectively, caused no deleterious effects.

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