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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Dynacirc

$41.6560 capsules/5 mg
price without discount in nearest pharmacy. Price may vary.

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Isradipine volume of distribution

The total body clearance of Isradipine is 1.4 L/min and the apparent volume of distribution is 3 L/kg.

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2018 Statistics

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Total savings $4,735,080

What is Isradipine

Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension.

Isradipine mechanism of action

Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. There are at least five different types of calcium channels in i Homo sapiens /i : L-, N-, P/Q-, R- and T-type. CCBs target L-type calcium channels, the major channel in muscle cells that mediates contraction. Similar to other DHP CCBs, isradipine binds directly to inactive calcium channels stabilizing their inactive conformation. Since arterial smooth muscle depolarizations are longer in duration than cardiac muscle depolarizations, inactive channels are more prevalent in smooth muscle cells. Alternative splicing of the alpha-1 subunit of the channel gives isradipine additional arterial selectivity. At therapeutic sub-toxic concentrations, isradipine has little effect on cardiac myocytes and conduction cells.

Dosage forms of Isradipine

FormRouteStrength
Capsuleoral2.5 mg/1
Capsuleoral5 mg/1

Prescription Generics

true

International Brands

Isradipine

Synonyms

Dynacirc Isradipino

Manufacturers

Epic Pharma, LLC

CAS number

75695-93-1

UNII

YO1UK1S598

State

solid

Affected organisms

Humans and other mammals

Indication of Isradipine

For the management of mild to moderate essential hypertension. It may be used alone or concurrently with thiazide-type diuretics.

Toxicity of Isradipine

Symptoms of overdose include lethargy, sinus tachycardia, and transient hypotension. Significant lethality was observed in mice given oral doses of over 200 mg/kg and rabbits given about 50 mg/kg of isradipine. Rats tolerated doses of over 2000 mg/kg without effects on survival.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Isradipine on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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