Save up -80% on Ivermectin
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2018 Price of Ivermectin
Stromectol 3 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Ivermectin volume of distribution
The volume of distribution is 3 to 3.5 L/kg and it does not cross the blood-brain barrier.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ivermectin
Ivermectin is a broad-spectrum anti-parasite medication. It was first marketed under the name Stromectol and used against worms (except tapeworms), but, in 2012, it was approved for the topical treatment of head lice infestations in patients 6 months of age and older, and marketed under the name Sklice as well. Ivermectin is mainly used in humans in the treatment of onchocerciasis, but is also effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis).
Ivermectin mechanism of action
Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Ivermectin also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. Ivermectin may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms.
Dosage forms of Ivermectin
Edenbridge Pharmaceuticals, LLC
Parasitic nematodes and other roundworms
Indication of Ivermectin
For the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite iStrongyloides stercoralis /i. Also for the treatment of onchocerciasis (river blindness) due to the nematode parasite iOnchocerca volvulus /i. Can be used to treat scabies caused by iSarcoptes scabiei /i.
Toxicity of Ivermectin
LD sub50 /sub = 29.5 mg/kg (Mouse, oral). LD sub50 /sub = 10 mg/kg (Rat, oral). Adverse effects include muscle or joint pain, dizziness, fever, headache, skin rash, fast heartbeat.
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