Save up -80% on Ixabepilone
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2018 Price of Ixabepilone
* price without discount in nearest pharmacy. Price may vary.
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Ixabepilone volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ixabepilone
Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. On October 16, 2007, the U.S. Food and Drug Administration approved ixabepilone for the treatment of aggressive metastatic or locally advanced breast cancer no longer responding to currently available chemotherapies. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. Ixabepilone is a semisynthetic analogue of epothilone B. It has a lactone actam modification that minimizes susceptibility to esterase degradation.
Ixabepilone mechanism of action
Binding of Ixabepilone to beta-tubulins (e.g. beta-III tubulin) stabilizes microtubules. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing. Like taxol, Ixabepilone binds to the -tubulin heterodimer subunit. Once bound, the rate of -tubulin dissociation decreases, thus stabilizing the microtubules.
Dosage forms of Ixabepilone
Aza-epothilone B Azaepothilone B
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Indication of Ixabepilone
Investigated for use/treatment in breast cancer, head and neck cancer, melanoma, lung cancer, lymphoma (non-hodgkin’s), prostate cancer, renal cell carcinoma, and cancer/tumors (unspecified).
Toxicity of Ixabepilone
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