Save up -80% on Ixabepilone

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Ixabepilone

$

* price without discount in nearest pharmacy. Price may vary.

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Ixabepilone volume of distribution

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What is Ixabepilone

Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. On October 16, 2007, the U.S. Food and Drug Administration approved ixabepilone for the treatment of aggressive metastatic or locally advanced breast cancer no longer responding to currently available chemotherapies. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. Ixabepilone is a semisynthetic analogue of epothilone B. It has a lactone actam modification that minimizes susceptibility to esterase degradation.

Ixabepilone mechanism of action

Binding of Ixabepilone to beta-tubulins (e.g. beta-III tubulin) stabilizes microtubules. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing. Like taxol, Ixabepilone binds to the -tubulin heterodimer subunit. Once bound, the rate of -tubulin dissociation decreases, thus stabilizing the microtubules.

Dosage forms of Ixabepilone

FormRouteStrength
Kit
Prescription Generics

false

International Brands

Ixempra

Synonyms

Aza-epothilone B Azaepothilone B

Manufacturers

R Pharm Us Operating, Llc

CAS number

219989-84-1

UNII

K27005NP0A

State

solid

Affected organisms

Indication of Ixabepilone

Investigated for use/treatment in breast cancer, head and neck cancer, melanoma, lung cancer, lymphoma (non-hodgkin’s), prostate cancer, renal cell carcinoma, and cancer/tumors (unspecified).

Toxicity of Ixabepilone

RX24 Drugs Disclaimer: before buying a Ixabepilone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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