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2018 Price of Ixazomib
* price without discount in nearest pharmacy. Price may vary.
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Ixazomib volume of distribution
The steady-state volume of distribution is 543 L.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ixazomib
Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortezomib (the first PI approved for multiple myeloma therapy) in the control of myeloma growth and prevention of bone loss. Ixazomib citrate is marketed by Takeda Pharmaceuticals under the brand name Ninlaro, which is a prodrug that becomes quickly converted to its active metabolite, ixazomib, after administration.
Ixazomib mechanism of action
Ixazomib is an N-capped dipeptidyl leucine boronic acid which reversibly inhibits the CT-L proteolytic ( 5) site of the 20S proteasome. At higher concentrations, ixazomib also seems to inhibit the proteolytic 1 and 2 subunits and to induce accumulation of ubiquitinated proteins.
Dosage forms of Ixazomib
Takeda Canada Inc
Humans and other mammals
Indication of Ixazomib
Ixazomib is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy.
Toxicity of Ixazomib
Drug-induced liver injury, hepatocellular injury, hepatic steatosis, hepatitis cholestatic and hepatotoxicity have each been reported in 1% of patients. Ixazomib can cause fetal harm when administered to pregnant women, and therefore it should also be advised to women of reproductive age to avoid becoming pregnant on ixazomib.
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