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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Ninlaro

$3,389

2.3mg

* price without discount in nearest pharmacy. Price may vary.

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Ixazomib volume of distribution

The steady-state volume of distribution is 543 L.

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What is Ixazomib

Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortezomib (the first PI approved for multiple myeloma therapy) in the control of myeloma growth and prevention of bone loss. Ixazomib citrate is marketed by Takeda Pharmaceuticals under the brand name Ninlaro, which is a prodrug that becomes quickly converted to its active metabolite, ixazomib, after administration.

Ixazomib mechanism of action

Ixazomib is an N-capped dipeptidyl leucine boronic acid which reversibly inhibits the CT-L proteolytic ( 5) site of the 20S proteasome. At higher concentrations, ixazomib also seems to inhibit the proteolytic 1 and 2 subunits and to induce accumulation of ubiquitinated proteins.

Dosage forms of Ixazomib

DrugDosageQuantityPrice
Ninlaro2.3mg1 capsule$3,402
Ninlaro3mg1 capsule$3,481
Ninlaro4mg1 capsule$3,389
Prescription Generics

false

International Brands

Ninlaro

Synonyms

Manufacturers

Takeda Canada Inc

CAS number

1072833-77-2

UNII

71050168A2

State

Affected organisms

Humans and other mammals

Indication of Ixazomib

Ixazomib is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy.

Toxicity of Ixazomib

Drug-induced liver injury, hepatocellular injury, hepatic steatosis, hepatitis cholestatic and hepatotoxicity have each been reported in 1% of patients. Ixazomib can cause fetal harm when administered to pregnant women, and therefore it should also be advised to women of reproductive age to avoid becoming pregnant on ixazomib.

RX24 Drugs Disclaimer: before buying a Ixazomib on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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