Save up -80% on Ketoconazole
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Nizoral
|$37.45||1 tube (60g) 2% cream|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Ketoconazole coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Ketoconazole every time. What are you waiting for? Claim your prescription drug card now!
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Ketoconazole volume of distribution
The mean apparent volume of distribution was 88.31 (+/- 68.72) liters.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ketoconazole
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
Ketoconazole mechanism of action
Ketoconazole interacts with 14-alpha; demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.
Dosage forms of Ketoconazole
|Aerosol, foam||topical||20 mg/g|
|Aerosol, foam||topical||2 g/100g|
Indication of Ketoconazole
For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Toxicity of Ketoconazole
Hepatotoxicity, LD sub 50 /sub =86 mg/kg (orally in rat)
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