Save up -80% on Ketoconazole

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Ketoconazole

Ketoconazole 2% cream

$1.1

g

* price without discount in nearest pharmacy. Price may vary.

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Ketoconazole volume of distribution

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What is Ketoconazole

Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.

Ketoconazole mechanism of action

Ketoconazole interacts with 14-alpha; demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.

Dosage forms of Ketoconazole

FormRouteStrength
Aerosol, foamtopical20 mg/g
Aerosol, foamtopical2 g/100g
Creamtopical20 mg/g
Prescription Generics

true

International Brands

Apo-ketoconazole

Synonyms

Extina Ketoconazol

Manufacturers

Apotex Inc

CAS number

65277-42-1

UNII

R9400W927I

State

solid

Affected organisms

Fungi

Indication of Ketoconazole

For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.

Toxicity of Ketoconazole

Hepatotoxicity, LD sub 50 /sub =86 mg/kg (orally in rat)

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