Save up -80% on Ketoprofen
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2018 Price of Ketoprofen
Ketoprofen 50 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Ketoprofen volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ketoprofen
Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Ketoprofen mechanism of action
The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Dosage forms of Ketoprofen
2-(3-Benzoylphenyl)propionic acid 3-Benzoyl-alpha-methylbenzeneacetic acid
Physicians Total Care, Inc.
Humans and other mammals
Indication of Ketoprofen
For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.
Toxicity of Ketoprofen
LD sub 50 /sub =62.4 mg/kg (rat, oral). p Symptoms of overdose include drowsiness, vomiting and abdominal pain. /p p Side effects are usually mild and mainly involved the GI tract. Most common adverse GI effect is dyspepsia (11% of patients). May cause nausea, diarrhea, abdominal pain, constipation and flatulence in greater than 3% of patients.
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