Save up -80% on Ketotifen
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2018 Price of Ketotifen
Zaditor 0.025% eye drops
* price without discount in nearest pharmacy. Price may vary.
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Ketotifen volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ketotifen
A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
Ketotifen mechanism of action
Ketotifen is a relatively selective, non-competitive histamine antagonist (H1-receptor) and mast cell stabilizer. Ketotifen inhibits the release of mediators from mast cells involved in hypersensitivity reactions. Decreased chemotaxis and activation of eosinophils have also been demonstrated. Ketotifen also inhibits cAMP phosphodiesterase. Properties of ketotifen which may contribute to its antiallergic activity and its ability to affect the underlying pathology of asthma include inhibition of the development of airway hyper-reactivity associated with activation of platelets by PAF (Platelet Activating Factor), inhibition of PAF-induced accumulation of eosinophils and platelets in the airways, suppression of the priming of eosinophils by human recombinant cytokines and antagonism of bronchoconstriction due to leukotrienes. Ketotifen inhibits of the release of allergic mediators such as histamine, leukotrienes C4 and D4(SRS-A) and PAF.
Dosage forms of Ketotifen
|Solution/ drops||ophthalmic||.35 mg/mL|
Bausch Lomb Incorporated
Humans and other mammals
Indication of Ketotifen
Indicated as an add-on or prophylactic oral medication in the chronic treatment of mild atopic asthmatic children. Also used as self-medication for the temporary relief of itching of the eye due to allergic conjunctivitis (ophthalmic).
Toxicity of Ketotifen
Adverse reactions include headaches, conjunctival injection and rhinitis.
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